Thiol-Poly(Sodium Styrene Sulfonate) (PolyNaSS-SH) Gold Complexes: From a Chemical Design to a One-Step Synthesis of Hybrid Gold Nanoparticles and Their Interaction with Human Proteins - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue ACS Omega Année : 2020

Thiol-Poly(Sodium Styrene Sulfonate) (PolyNaSS-SH) Gold Complexes: From a Chemical Design to a One-Step Synthesis of Hybrid Gold Nanoparticles and Their Interaction with Human Proteins

Ceĺine Falentin-Daudre
  • Fonction : Auteur
Mounia Aitouakli
  • Fonction : Auteur
Jean Sebastien Baumann
  • Fonction : Auteur
Vincent Humblot
Veronique Migonney
Jolanda Spadavecchia

Résumé

This study highlights recent advances in the synthesis of nanoconjugates based on gold (Au(III)) complex with a bioactive polymer bearing sulfonate groups called thiol-poly(sodium styrene sulfonate) (PolyNaSS-SH) with various molecular weights (5, 10, and 35 kDa). The three nanomaterials differ substantially in shape and structure. In particular, for PolyNaSS-SH of 35 kDa, we obtained a characteristic core−shell flower shape after chelation of the Au(III) ions and successively reduction with sodium borohydride (NaBH 4). The mechanism of formation of the hybrid nanoparticles (PolyNaSS-SH@AuNPs (35 kDa) and their interactions between plasmatic proteins (human serum albumin (HSA), collagen I (Col 1), and fibronectin (Fn)) were deeply studied from a chemical and physical point of view by using several analytical techniques such as Raman spectroscopy, UV−visible, transmission electron microscopy (TEM), 1 H NMR, and X-ray photoelectron spectroscopy (XPS).
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hal-02571960 , version 1 (13-05-2020)

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Ceĺine Falentin-Daudre, Mounia Aitouakli, Jean Sebastien Baumann, Nadia Bouchemal, Vincent Humblot, et al.. Thiol-Poly(Sodium Styrene Sulfonate) (PolyNaSS-SH) Gold Complexes: From a Chemical Design to a One-Step Synthesis of Hybrid Gold Nanoparticles and Their Interaction with Human Proteins. ACS Omega, 2020, pp.8137-8145. ⟨10.1021/acsomega.0c00376⟩. ⟨hal-02571960⟩
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