The Importance Of Naturally Attenuated Sars-Cov-2 In The Fight Against Covid-19 - Archive ouverte HAL
Article Dans Une Revue Environmental Microbiology Année : 2020

The Importance Of Naturally Attenuated Sars-Cov-2 In The Fight Against Covid-19

J. Armengaud
René Courcol
  • Fonction : Auteur
Antoine Danchin
  • Fonction : Auteur
Daniel Tillett
  • Fonction : Auteur

Résumé

The current SARS-CoV-2 pandemic is wreaking havoc throughout the world and has rapidly become a global health emergency. A central question concerning COVID-19 is why some individuals become sick and others not. Many have pointed already at variation in risk factors between individuals. However, the variable outcome of SARS-CoV-2 infections may, at least in part, be due also to differences between the viral subspecies with which individuals are infected. A more pertinent question is how we are to overcome the current pandemic. A vaccine against SARS-CoV-2 would offer significant relief, although vaccine developers have warned that design, testing, and production of vaccines may take a year if not longer. Vaccines are based on a handful of different designs (1), but the earliest vaccines were based on live, attenuated virus. As has been the case for other viruses during earlier pandemics, SARS-CoV-2 will mutate and may naturally attenuate over time (2). What makes the current pandemic unique is that, thanks to state-of-the-art nucleic acid sequencing technologies, we can follow in detail how SARS-CoV-2 evolves while it spreads. We argue that knowledge of naturally emerging attenuated SARS-CoV-2 variants across the globe should be of key interest in our fight against the pandemic. This article is protected by copyright. All rights reserved.
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hal-02571406 , version 1 (08-12-2021)

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J. Armengaud, Agnès Delaunay-Moisan, Jean-Yves Thuret, Eelco Van Anken, Diego Acosta-Alvear, et al.. The Importance Of Naturally Attenuated Sars-Cov-2 In The Fight Against Covid-19. Environmental Microbiology, 2020, 22 (6), pp.1997-2000. ⟨10.1111/1462-2920.15039⟩. ⟨hal-02571406⟩
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