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Article Dans Une Revue International Journal of Tuberculosis and Lung Disease Année : 2020

Tuberculosis trends in a hot-spot region in Paris, France

Résumé

SETTING: Tuberculosis (TB) incidence is declining overall in France, but not in Paris where some areas remain relative hot spots for TB.OBJECTIVES: To obtain a better knowledge of local TB epidemiology in order to facilitate control measures.DESIGN: Analysis of demographic data of TB patients diagnosed at the Bichat-Claude Bernard Hospital from 2007 to 2016, with spoligotyping of Mycobacterium tuberculosis complex isolates.RESULTS: During the study period, 1096 TB patients were analysed. The incidence of TB diagnosis was stable, averaging 115 patients per year, predominantly males (71%), foreign-born (81%), with pulmonary TB (77%) and negative HIV serology (88%). The mean age of foreign-born TB patients decreased over the study period, most significantly in recent arrivals in France, whose average age decreased by two years (P = 0.001). The time period between arrival in France and being diagnosed with active TB decreased annually significantly by 0.75 years (P = 0.02). The proportion of L4.6.2/Cameroon and L2/Beijing sub-lineages increased annually by 0.7% (P \textless 0.05). Multi-drug resistant strains, representing 4% of all strains, increased annually by 0.75% (P = 0.03)CONCLUSION: The number of TB patients remained high in northern Paris and the surrounding suburbs, suggesting the need for increased control measures.
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Dates et versions

hal-02571403 , version 1 (12-05-2020)

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C. Pierre-Audigier, C. Talla, A.-K. Alame-Emane, B. Audigier, N. Grall, et al.. Tuberculosis trends in a hot-spot region in Paris, France. International Journal of Tuberculosis and Lung Disease, 2020, 24 (4), pp.428--435. ⟨10.5588/ijtld.19.0305⟩. ⟨hal-02571403⟩
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