Tear of Lipid Membranes by Nanoparticles - Archive ouverte HAL Access content directly
Journal Articles Soft Matter Year : 2022

Tear of Lipid Membranes by Nanoparticles

Jérôme Combet
  • Function : Author
  • PersonId : 1082503
  • IdRef : 202425886
Marc Schmutz
Carlos Marques
Connectez-vous pour contacter l'auteur

Abstract

Health concerns associated with the advent of nanotechnologies have risen sharply when it was found that particles of nanoscopic dimensions reach the cell lumina. Plasma and organelle lipid membranes, which are exposed to both the incoming and the engulfed nanoparticles, are the primary targets of possible disruptions. However, reported adhesion, invagination and embedment of nanoparticles (NPs) do not compromise the membrane integrity, precluding direct bilayer damage as a mechanism for toxicity. Here it is shown that a lipid membrane can be torn by small enough nanoparticles, thus unveiling mechanisms for how lipid membrane can be compromised by tearing from nanoparticles. Surprisingly, visualization by cryo transmission electron microscopy (cryo-TEM) of liposomes exposed to nanoparticles revealed also that liposomal laceration is prevented by particle abundance. Membrane destruction results thus from a subtle particle-membrane interplay that is here elucidated. This brings into a firmer molecular basis the theorized mechanisms of nanoparticle effects on lipid bilayers and paves the way for a better assessment of nanoparticle toxicity.
Fichier principal
Vignette du fichier
Er-Rafik_et_al_SoftMatter_2022_18_3318-3322_with_ESI.pdf (3.18 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

hal-02568518 , version 1 (09-05-2020)
hal-02568518 , version 2 (07-05-2022)

Licence

Attribution - NonCommercial - ShareAlike

Identifiers

Cite

Meriem Er-Rafik, Khalid Ferji, Jérôme Combet, Olivier Sandre, Sébastien Lecommandoux, et al.. Tear of Lipid Membranes by Nanoparticles. Soft Matter, 2022, 18 (17), pp.3318-3322. ⟨10.1039/D2SM00179A⟩. ⟨hal-02568518v2⟩
176 View
88 Download

Altmetric

Share

Gmail Facebook X LinkedIn More