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Article Dans Une Revue Innovation and Research in BioMedical engineering Année : 2020

Real Time Intraoperative Functional Brain Mapping Based on RGB Imaging

Résumé

Intraoperative optical imaging is a localization technique for the functional areas of the human brain cortex during neurosurgical procedures. However, it still lacks robustness to be used as a clinical standard. In particular new biomarkers of brain functionality with improved sensitivity and specificity are needed. We present a method for the real time identification of the activated cortical areas based on the analysis of the cortical hemodynamic using a RGB camera and a white light source. We measure the quantitative oxy and deoxy-hemoglobin concentration changes in the human brain cortex with the modified Beer-Lambert law and Monte Carlo simulations. A functional model has been implemented to define in real time a binary biomarker of the cortical activation following neuronal activation by physiological stimuli. The results show a good correlation between the computed activation maps and the brain areas localized by electrical brain stimulation. We demonstrate that a RGB camera combined with a quantitative modeling of brain hemodynamics biomarkers can evaluate in real time the functional areas during neurosurgery and serve as a tool of choice to complement electrical brain stimulation.
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Dates et versions

hal-02568247 , version 1 (24-05-2023)

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Paternité - Pas d'utilisation commerciale

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C. Caredda, L. Mahieu-Williame, R. Sablong, M. Sdika, J. Guyotat, et al.. Real Time Intraoperative Functional Brain Mapping Based on RGB Imaging. Innovation and Research in BioMedical engineering, 2020, ⟨10.1016/j.irbm.2020.04.004⟩. ⟨hal-02568247⟩
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