Zein-based filaments containing 20 weight% [Lidocainium][Ibuprofenate] used as a doubly Active Pharmaceutical Ingredient-Ionic Liquid (API-IL) were obtained by extrusion at 130°C.The plasticizing effect of the active ingredient on the zein amorphous matrix was assessed by Differential Scanning Calorimetry, with the decrease of the glass transition temperature (Tg) from 77°C, for the raw zein, to 53°C. After storage under standard conditions (relative humidity 59%, 20°C) the extrudates were rigid, with a high storage modulus (E′) at ambient temperature of about 3 GPa. They had a main mechanical relaxation (Tα) beginning at 55°C and leading to their flowing at temperature above 130°C, as determined by Dynamic Mechanical Analysis, with E′ below 1 MPa and tanδ above 1. Their structure was evaluated by Wide Angle X-ray Scattering and NMR analyses were used to evaluate the API-IL stability that was shown after thermomechanical processing. Release experiments performed under simulated physiological conditions on filaments evidenced a release of 85% after 7 days immersion. These results demonstrate the interest of using an API-IL to act as plasticizer for a resorbable biopolymer. 2 The resulting material can be shaped by continuous thermomechanical process and used as drug delivery system.