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Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2014

Plasmodium falciparum Founder Populations in Western Cambodia Have Reduced Artemisinin Sensitivity In Vitro

Résumé

Reduced Plasmodium falciparum sensitivity to short-course artemisinin (ART) monotherapy manifests as a long parasite clearance half-life. We recently defined three parasite founder populations with long half-lives in Pursat, western Cambodia, where reduced ART sensitivity is prevalent. Using the ring-stage survival assay, we show that these founder populations have reduced ART sensitivity in vitro at the early ring stage of parasite development and that a genetically admixed population contains subsets of parasites with normal or reduced ART sensitivity.

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hal-02560673 , version 1 (02-05-2020)

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Chanaki Amaratunga, Benoit Witkowski, Dalin Dek, Vorleak Try, Nimol Khim, et al.. Plasmodium falciparum Founder Populations in Western Cambodia Have Reduced Artemisinin Sensitivity In Vitro. Antimicrobial Agents and Chemotherapy, 2014, 58 (8), pp.4935-4937. ⟨10.1128/AAC.03055-14⟩. ⟨hal-02560673⟩

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