Endowing carbon nanotubes with biological and biomedical properties by chemical modifications. - Archive ouverte HAL
Article Dans Une Revue Advanced drug delivery reviews Année : 2013

Endowing carbon nanotubes with biological and biomedical properties by chemical modifications.

Alessia Battigelli
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Tatiana da Ros
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Maurizio Prato
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Alberto Bianco

Résumé

The scope of nanotechnology is gaining importance in biology and medicine. Carbon nanotubes (CNTs) have emerged as a promising tool due to their unique properties, high specific surface area, and capacity to cross biological barriers. These properties offer a variety of opportunities for applications in nanomedicine, such as diagnosis, disease treatment, imaging, and tissue engineering. Nevertheless, pristine CNTs are insoluble in water and in most organic solvents; thereby functionalization of their surface is necessary to increase biocompatibility. Derivatization of CNTs also gives the possibility to conjugate different biological and bioactive molecules including drugs, proteins, and targeting ligands. This review focuses on the chemical modifications of CNTs that have been developed to impart specific properties for biological and medical purposes. Biomolecules can be covalently grafted or non-covalently adsorbed on the nanotube surface. In addition, the inner core of CNTs can be exploited to encapsulate drugs, nanoparticles, or radioactive elements.

Dates et versions

hal-02558873 , version 1 (29-04-2020)

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Citer

Alessia Battigelli, Cécilia Ménard-Moyon, Tatiana da Ros, Maurizio Prato, Alberto Bianco. Endowing carbon nanotubes with biological and biomedical properties by chemical modifications.. Advanced drug delivery reviews, 2013, 65 (15), pp.1899-1920. ⟨10.1016/j.addr.2013.07.006⟩. ⟨hal-02558873⟩
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