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Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2018

Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic

Résumé

Plasmodium falciparum artemisinin-resistant parasites can be evaluated by examining polymorphisms in the kelch (PfK13) domain. A total of 69 samples from patients with falciparum malaria were analyzed. All samples were from areas in states in Brazil where the parasite was endemic: Acre (n = 14), Amapá (n = 15), Amazonas (n = 30), and Pará (n = 10). After DNA alignment with the 3D7 reference sequence, all samples were found to be wild type. These data provide a baseline for PfK13 and reinforce the pertinence of artemisinin combination therapy in Brazilian areas.

Domaines

Parasitologie

Dates et versions

hal-02558713 , version 1 (29-04-2020)

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Citer

Larissa Rodrigues Gomes, Aline Lavigne, Cassio Leonel Peterka, Patrícia Brasil, Didier Ménard, et al.. Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic. Antimicrobial Agents and Chemotherapy, 2018, 62 (10), ⟨10.1128/AAC.00354-18⟩. ⟨hal-02558713⟩
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