Childhood CT scans and cancer risk impact of predisposing factors for cancer on the risk estimates - Archive ouverte HAL
Article Dans Une Revue Journal of radiological protection official journal of the Society for Radiological Protection Année : 2016

Childhood CT scans and cancer risk impact of predisposing factors for cancer on the risk estimates

Résumé

To investigate the role of cancer predisposing factors (PFs) on the associations between paediatric computed tomography (CT) scan exposures and subsequent risk of central nervous system (CNS) tumours and leukaemia. A cohort of children who underwent a CT scan in 2000-2010 in 23 French radiology departments was linked with the national childhood cancers registry and national vital status registry; information on PFs was retrieved through hospital discharge databases. In children without PF, hazard ratios of 1.07 (95% CI 0.99-1.10) for CNS tumours (15 cases) and 1.16 (95% CI 0.77-1.27) for leukaemia (12 cases) were estimated for each 10 mGy increment in CT x-rays organ doses. These estimates were similar to those obtained in the whole cohort. In children with PFs, no positive dose-risk association was observed, possibly related to earlier non-cancer mortality in this group. Our results suggest a modifying effect of PFs on CT-related cancer risks, but need to be confirmed by longer follow-up and other studies.
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Dates et versions

hal-02557560 , version 1 (28-04-2020)

Identifiants

Citer

N. Journy, T. Roué, E. Cardis, H.D. Le Pointe, H. Brisse, et al.. Childhood CT scans and cancer risk impact of predisposing factors for cancer on the risk estimates. Journal of radiological protection official journal of the Society for Radiological Protection, 2016, 36 (1), pp.N1-N7. ⟨10.1088/0952-4746/36/1/N1⟩. ⟨hal-02557560⟩
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