Article Dans Une Revue Methods in Molecular Biology Année : 2020

LecA (PA-IL), a Galactose-Binding Lectin from Pseudomonas aeruginosa

Résumé

LecA/PA-IL (Pfam PF07828) is a soluble galactose-binding lectin from bacterium Pseudomonas aeruginosa. The lectin is specific for α-galactose present on glycosphingolipids of the globoside family and has therefore been proposed to play a role in cell adhesion and in internalization of bacteria in epithelial cells. The lectin has also direct toxic activity. Search for high affinity inhibitors can be performed on the recombinant lectin, with use of surface plasmon resonance assays and structural studies.

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hal-02554317 , version 1 (25-04-2020)

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Sakonwan Kuhaudomlarp, Émilie Gillon, Annabelle Varrot, Anne Imberty. LecA (PA-IL), a Galactose-Binding Lectin from Pseudomonas aeruginosa. Methods in Molecular Biology, 2020, Lectin purification and analysis, 2132, pp.257-266. ⟨10.1007/978-1-0716-0430-4_25⟩. ⟨hal-02554317⟩
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