Invasion phenomena for heterogeneous reaction-diffusion equations are contemporary and challenging questions in applied mathematics. In this paper we are interested in the question of spreading for a reaction-diffusion equation when the subdomain where the reaction term is positive is shifting/contracting at a given speed c. This problem arises in particular in the modelling of the impact of climate change on population dynamics. By placing ourselves in the appropriate moving frame, this leads us to consider a reaction-diffusion-advection equation with a heterogeneous in space reaction term, in dimension N ≥ 1. We investigate the behaviour of the solution u depending on the value of the advection constant c, which typically stands for the velocity of climate change. We find that, when the initial datum is compactly supported, there exists precisely three ranges for c leading to drastically different situations. In the lower speed range the solution always spreads, while in the upper range it always vanishes. More surprisingly, we find that that both spreading and vanishing may occur in an intermediate speed range. The threshold between those two outcomes is always sharp, both with respect to c and to the initial condition. We also briefly consider the case of an exponentially decreasing initial condition, where we relate the decreasing rate of the initial condition with the range of values of c such that spreading occurs.