Response of the human gut and saliva microbiome to urbanization in cameroon - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2020

Response of the human gut and saliva microbiome to urbanization in cameroon

Ana Lokmer
  • Fonction : Auteur
Sophie Aflalo
  • Fonction : Auteur
Sophie Lafosse
Francis Ekwin Tabe
  • Fonction : Auteur
Mathilde Poyet
  • Fonction : Auteur
Mathieu Groussin
  • Fonction : Auteur
  • PersonId : 774193
  • IdRef : 185886299
Rihlat Said-Mohamed
  • Fonction : Auteur
Laure Ségurel

Résumé

Urban populations from highly industrialized countries are characterized by a lower gut bacterial diversity as well as by changes in composition compared to rural populations from less industrialized countries. to unveil the mechanisms and factors leading to this diversity loss, it is necessary to identify the factors associated with urbanization-induced shifts at a smaller geographical scale, especially in less industrialized countries. to do so, we investigated potential associations between a variety of dietary, medical, parasitological and socio-cultural factors and the gut and saliva microbiomes of 147 individuals from three populations along an urbanization gradient in cameroon. We found that the presence of Entamoeba sp., a commensal gut protozoan, followed by stool consistency, were major determinants of the gut microbiome diversity and composition. interestingly, urban individuals have retained most of their gut eukaryotic and bacterial diversity despite significant changes in diet compared to the rural areas, suggesting that the loss of bacterial microbiome diversity observed in industrialized areas is likely associated with medication. finally, we observed a weak positive correlation between the gut and the saliva microbiome diversity and composition, even though the saliva microbiome is mainly shaped by habitat-related factors.
Fichier principal
Vignette du fichier
s41598-020-59849-9.pdf (2 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02546558 , version 1 (18-04-2020)

Identifiants

Citer

Ana Lokmer, Sophie Aflalo, Norbert N. Amougou, Sophie Lafosse, Alain Froment, et al.. Response of the human gut and saliva microbiome to urbanization in cameroon. Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-59849-9⟩. ⟨hal-02546558⟩
100 Consultations
68 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More