The synthesis of a quantum circuit consists in decomposing a unitary matrix into a series of elementary operations. In this paper, we propose a circuit synthesis method based on the QR factorization via Householder transformations. We provide a two-step algorithm: during the rst step we exploit the speci c structure of a quantum operator to compute its QR factorization, then the factorized matrix is used to produce a quantum circuit. We analyze several costs (circuit size and computational time) and compare them to existing techniques from the literature. For a nal quantum circuit twice as large as the one obtained by the best existing method, we accelerate the computation by orders of magnitude.