Progress in integrative systems biology, physiology and medicine: towards a scale-relative biology - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Eur.Phys.J.A Année : 2020

Progress in integrative systems biology, physiology and medicine: towards a scale-relative biology

Charles Auffray
  • Fonction : Auteur
Denis Noble
  • Fonction : Auteur
Philip Turner
  • Fonction : Auteur

Résumé

In this paper we present a review of progress in addressing the challenge to understand and describe the vast complexity and multi-level organisation associated with biological systems. We begin with a review of past and current approaches, key lessons, and unresolved challenges, which require a new conceptual framework to address them. After summarizing the core of the problem, which is linked to computational complexity, we review recent developments within the theoretical framework of scale relativity, which offers new insights into the emergence of structure and function (at multiple scales), providing a new integrative approach to biological systems. The theoretical framework describes the critical role of thermodynamics and quantum vacuum fluctuations in the emergence of charge-induced macroscopic quantum fields (effectively a new quantum field theory) at multiple scales, which underpin a macroscopic quantum description of biological systems as a complex exemplar of condensed matter. The theory is validated through a new biomimetic experimental approach, which leads to the emergence of plant and individual cell-like structures with the intrinsic capacity to divide, differentiate and form multicellular structures. We discuss how this theoretical framework could be applied to extend our understanding of cardiac systems biology and physiology, and challenges such as cancer and neurodegenerative disease. We also consider the potential of these new insights to support a new approach to the development of emerging quantum technologies.
Fichier principal
Vignette du fichier
Auffray2020_Article_ProgressInIntegrativeSystemsBi.pdf (2.84 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-02542819 , version 1 (16-04-2021)

Identifiants

Citer

Charles Auffray, Denis Noble, Laurent Nottale, Philip Turner. Progress in integrative systems biology, physiology and medicine: towards a scale-relative biology. Eur.Phys.J.A, 2020, 56 (3), pp.88. ⟨10.1140/epja/s10050-020-00090-3⟩. ⟨hal-02542819⟩
62 Consultations
88 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More