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Article Dans Une Revue FASEB Journal Année : 2004

Histopathological and cognitive defects induced by Nef in the brain

Résumé

Complex mechanisms of human immunodeficiency virus type-1 (HIV-1) brain pathogenesis suggest the contribution of individual HIV-1 gene products. Among them, the Nef protein has been reported to harbor a major determinant of pathogenicity in AIDS-like disease. The goal of the present study was to determine whether Nef protein expressed in vivo by primary macrophages could induce a brain toxicity also affecting the behavior of the rat. To achieve this goal we grafted Nef-transduced macrophages into the rat hippocampus. Two months post-transplantation, we observed that Nef induces monocyte/macrophage recruitment, expression of TNF-alpha, and astrogliosis. No apoptotic event was detected. We further demonstrated that Nef neurotoxicity is associated with cognitive deficits.
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hal-02541843 , version 1 (14-04-2020)

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Elodie Mordelet, Karima Kissa, Arnaud Cressant, Françoise Gray, Simona Ozden, et al.. Histopathological and cognitive defects induced by Nef in the brain. FASEB Journal, 2004, 18 (15), pp.1851-1861. ⟨10.1096/fj.04-2308com⟩. ⟨hal-02541843⟩
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