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Journal Articles Frontiers in Physics Year : 2020

Correlated Multimodal Imaging in Life Sciences: Expanding the Biomedical Horizon

Ludek Sefc
  • Function : Author
Paul Verkade
  • Function : Author
Julia Mannheim
  • Function : Author
Paul Slezak
  • Function : Author
Angelika Unterhuber
  • Function : Author
Martina Marchetti-Deschmann
  • Function : Author
Manfred Ogris
  • Function : Author
Dror Fixler
  • Function : Author
Stefan Geyer
  • Function : Author
Wolfgang Weninger
  • Function : Author
Stephan Handschuh
  • Function : Author
Thomas Wanek
  • Function : Author


The frontiers of bioimaging are currently being pushed toward the integration and correlation of several modalities to tackle biomedical research questions holistically and across multiple scales. Correlated Multimodal Imaging (CMI) gathers information about exactly the same specimen with two or more complementary modalities that-in combination-create a composite and complementary view of the sample (including insights into structure, function, dynamics and molecular composition). CMI allows to describe biomedical processes within their overall spatio-temporal context and gain a mechanistic understanding of cells, tissues, diseases or organisms by untangling their molecular mechanisms within their native environment. The two best-established CMI implementations for small animals and model organisms are hardware-fused platforms in preclinical imaging (Hybrid Imaging) and Correlated Light and Electron Microscopy (CLEM) in biological imaging. Although the merits of Preclinical Hybrid Imaging (PHI) and CLEM are well-established, both approaches would benefit from standardization of protocols, ontologies and data handling, and the development of optimized and advanced implementations. Specifically, CMI pipelines that aim at bridging preclinical and biological imaging beyond CLEM and PHI are rare but bear great potential to substantially advance both bioimaging and biomedical research. CMI faces three main
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Dates and versions

hal-02539357 , version 1 (28-04-2020)



Andreas Walter, Perrine Paul-Gilloteaux, Birgit Plochberger, Ludek Sefc, Paul Verkade, et al.. Correlated Multimodal Imaging in Life Sciences: Expanding the Biomedical Horizon. Frontiers in Physics, 2020, 8, ⟨10.3389/fphy.2020.00047⟩. ⟨hal-02539357⟩
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