The prolipoprotein diacylglyceryl transferase (Lgt) of Enterococcus faecalis contributes to virulence - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Microbiology Année : 2012

The prolipoprotein diacylglyceryl transferase (Lgt) of Enterococcus faecalis contributes to virulence

Résumé

Enterococcus faecalis is an opportunistic pathogen responsible for nosocomial infections. Lipoproteins in Gram-positive bacteria are translocated across the plasma membrane and anchored by the fatty acid group. They perform critical roles, with some described as virulence determinants. The aim of this study was to explore the roles of E. faecalis lipoproteins in the stress response and virulence. We constructed a mutant affected in the predicted prolipoprotein diacylglyceryl transferase gene lgt, and examined the role of Lgt in membrane anchoring, growth, the stress response and virulence. Inactivation of lgt enhanced growth in a high concentration of Mn2+ or under oxidative stress in vitro, and significantly decreased virulence.
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hal-02528181 , version 1 (01-04-2020)

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Fany F. Reffuveille, Pascale Serror, Sylvie Chevalier, Aurelie A. Budin-Verneuil, Rabia R. Ladjouzi, et al.. The prolipoprotein diacylglyceryl transferase (Lgt) of Enterococcus faecalis contributes to virulence. Microbiology, 2012, 158 (3), pp.816-825. ⟨10.1099/mic.0.055319-0⟩. ⟨hal-02528181⟩
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