Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers
F. Coussy
(1)
,
R. El Botty
(2)
,
M. Lavigne
(3)
,
C. Gu
(3)
,
L. Fuhrmann
(3)
,
A. Briaux
(4)
,
L. de Koning
(5)
,
A. Dahmani
(6)
,
E. Montaudon
(6)
,
L. Morisset
(6)
,
L. Huguet
(2)
,
L. Sourd
(2)
,
P. Painsec
(2)
,
S. Chateau-Joubert
(7)
,
Thibaut Larcher
(8, 9)
,
S. Vacher
(4)
,
S. Melaabi
(10)
,
A. Vincent Salomon
(3)
,
E. Marangoni
(2)
,
I. Bieche
(2, 11, 12)
1
Unit of Pharmacogenomics, Department of Genetics,Laboratory of Preclinical Investigation, Department of Translational Research,Department of Medical Oncology
2 Laboratory of Preclinical Investigation, Department of Translational Research
3 Department of Biopathology
4 Unit of Pharmacogenomics, Department of Genetics
5 Translational Research Department, RPPA Platform
6 Laboratory of Preclinical Investigation, Department of Translational Research,
7 Biopôle Alfort
8 PAnTher - Physiopathologie Animale et bioThérapie du muscle et du système nerveux
9 APEX - Expertise en Anatomie Pathologique
10 Unit of Pharmacogenomics, Department of Genetics,
11 IC UM3 (UMR 8104 / U1016) - Institut Cochin
12 UPD5 - Université Paris Descartes - Paris 5
2 Laboratory of Preclinical Investigation, Department of Translational Research
3 Department of Biopathology
4 Unit of Pharmacogenomics, Department of Genetics
5 Translational Research Department, RPPA Platform
6 Laboratory of Preclinical Investigation, Department of Translational Research,
7 Biopôle Alfort
8 PAnTher - Physiopathologie Animale et bioThérapie du muscle et du système nerveux
9 APEX - Expertise en Anatomie Pathologique
10 Unit of Pharmacogenomics, Department of Genetics,
11 IC UM3 (UMR 8104 / U1016) - Institut Cochin
12 UPD5 - Université Paris Descartes - Paris 5
Thibaut Larcher
- Fonction : Auteur
- PersonId : 735738
- IdHAL : tlarcher
- ORCID : 0000-0002-0396-3190
- IdRef : 076698297
S. Vacher
- Fonction : Auteur
- PersonId : 1225392
- ORCID : 0000-0002-0042-6023
- IdRef : 148403921
I. Bieche
- Fonction : Auteur
- PersonId : 1285014
- ORCID : 0000-0002-2430-5429
- IdRef : 059803088
Résumé
Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers
Domaines
Sciences du Vivant [q-bio]Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Résumé |
en
Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers
|
Titre |
fr
Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers
|
Auteur(s) |
F. Coussy
1
, R. El Botty
2
, M. Lavigne
3
, C. Gu
3
, L. Fuhrmann
3
, A. Briaux
4
, L. de Koning
5
, A. Dahmani
6
, E. Montaudon
6
, L. Morisset
6
, L. Huguet
2
, L. Sourd
2
, P. Painsec
2
, S. Chateau-Joubert
7
, Thibaut Larcher
8, 9
, S. Vacher
4
, S. Melaabi
10
, A. Vincent Salomon
3
, E. Marangoni
2
, I. Bieche
2, 11, 12
1
Unit of Pharmacogenomics, Department of Genetics,Laboratory of Preclinical Investigation, Department of Translational Research,Department of Medical Oncology
( 1004199 )
- France
2
Laboratory of Preclinical Investigation, Department of Translational Research
( 557606 )
- France
3
Department of Biopathology
( 153351 )
- Rome
- Italie
4
Unit of Pharmacogenomics, Department of Genetics
( 557605 )
- France
5
Translational Research Department, RPPA Platform
( 557602 )
- France
6
Laboratory of Preclinical Investigation, Department of Translational Research,
( 557609 )
- France
7
Biopôle Alfort
( 1076908 )
- France
8
PAnTher -
Physiopathologie Animale et bioThérapie du muscle et du système nerveux
( 1004624 )
- Ecole Nationale Vétérinaire, Agroalimentaire et de l'Alimentation, Nantes-Atlantique (Oniris)
Atlanpole- La Chantrerie; CS. 40706
44307 Nantes Cedex 3 - France
- France
9
APEX -
Expertise en Anatomie Pathologique
( 1029258 )
- Ecole Nationale Vétérinaire, Agroalimentaire et de l'Alimentation, Nantes-Atlantique (Oniris) Atlanpole- La Chantrerie; CS. 4070644307 Nantes Cedex 3 - France
- France
10
Unit of Pharmacogenomics, Department of Genetics,
( 1004200 )
- France
11
IC UM3 (UMR 8104 / U1016) -
Institut Cochin
( 1004701 )
- 22 rue Méchain, 75014 Paris
- France
12
UPD5 -
Université Paris Descartes - Paris 5
( 301664 )
- 12, rue de l'École de Médecine - 75270 Paris cedex 06
- France
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Non spécifiée
|
Date de publication |
2020
|
Volume |
13
|
Numéro |
1
|
Page/Identifiant |
np
|
Public visé |
Scientifique
|
Domaine(s) |
|
DOI | 10.1186/s13045-020-0846-y |
ProdINRA | 496776 |
UT key WOS | 00517313400001 |
Origine :
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