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Article Dans Une Revue Tuberculosis Année : 2020

NTF-RINT, a new method for the epidemiological surveillance of MDR Mycobacterium tuberculosis L2/Beijing strains

Résumé

The most widely discussed antibiotic-resistant tuberculosis strains ("W" and "B0/W148", "CAO") belong to L2/Beijing Lineage and are characterized by IS6110 insertion sequences at the NTF locus. We present a high-throughput, microbead-based method, called NTF-RINT for detection of IS in NTF and Rifampicin and Isoniazid Typing. This method provides tuberculosis diagnostic confirmation, screens for the so-called modern L2/Beijing sublineage and detects mutations involved in resistance to Rifampicin (RIF) and Isoniazid (INH).
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hal-02502306 , version 1 (21-07-2022)

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Paternité - Pas d'utilisation commerciale

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Bernice J. Klotoe, Natalia Kurepina, Elena Zholdibayeva, S. Panaiotov, Barry N. Kreiswirth, et al.. NTF-RINT, a new method for the epidemiological surveillance of MDR Mycobacterium tuberculosis L2/Beijing strains. Tuberculosis, 2020, 120, pp.101894. ⟨10.1016/j.tube.2019.101894⟩. ⟨hal-02502306⟩
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