In this paper, an image processing to detect polyps in an intelligent Wireless Capsule Endoscopy (WCE) is presented. This processing will be integrated into the WCE. It is a new screening method to detect colorectal cancer (CRC). A motion estimation algorithm is used to follow a detected polyp and improve the pre-processing of our detection chain. With our methodology, the polyp detection rate is improved by up to 40% from 53% to 93.7%. The improved detection rate was validated with a large database of 20 video-colonoscopies (18,910 images).