In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis - Archive ouverte HAL Access content directly
Journal Articles Veterinary Research Year : 2020

In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis

Qi Xin
  • Function : Author
Miaomiao Yuan
  • Function : Author
Huanping Li
  • Function : Author
Xiaoxia Song
  • Function : Author
Jun Lu
  • Function : Author
Tao Jing
  • Function : Correspondent author
  • PersonId : 968471

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Abstract

AbstractEchinococcosis is a zoonotic disease caused by cestode species of the genus Echinococcus, which demonstrates considerable medical and veterinary concerns. The development of novel drugs for echinococcosis treatment is urgently needed. In this study, we demonstrated that lonidamine (LND) and 6-aminonicotinamide (6-AN) exhibited considerable in vitro effects against both larval- and adult-stage of E. granulosussensu stricto (s. s.) and E. multilocularis. The combination of LND and 6-AN exhibited a significantly higher activity than the single drug treatment. These results highlight the therapeutic potential of LND, 6-AN and the combination of LND and 6-AN for the treatment of echinococcosis.
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Dates and versions

hal-02495386 , version 1 (02-03-2020)

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Qi Xin, Miaomiao Yuan, Huanping Li, Xiaoxia Song, Jun Lu, et al.. In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis. Veterinary Research, 2020, 51 (1), pp.29. ⟨10.1186/s13567-020-00744-6⟩. ⟨hal-02495386⟩

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