Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2020

Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function

Résumé

Silver (Ag(I)) binding to consensus zinc fingers (ZFs) causes Zn(II) release inducing a gradual disruption of the hydrophobic core, followed by an overall conformational change and formation of highly stable AgnSn clusters. A compact eight-membered Ag4S4 structure formed by a CCCC ZF is the first cluster example reported for a single biological molecule. Ag(I)-induced conformational changes of ZFs can, as a consequence, affect transcriptional regulation and other cellular processes.
Fichier principal
Vignette du fichier
MAnuscrit-open-access-hal-02494376.pdf (1.86 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-02494376 , version 1 (05-11-2021)

Identifiants

Citer

Katarzyna Kluska, Manuel David Peris-Díaz, Dawid Płonka, Alexander Moysa, Michał Dadlez, et al.. Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function. Chemical Communications, 2020, 56 (9), pp.1329-1332. ⟨10.1039/c9cc09418k⟩. ⟨hal-02494376⟩
58 Consultations
24 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More