Article Dans Une Revue Synthetic Communications Année : 2019

Synthesis of new substituted imidazo[1,2-a]pyridinylpropenenitriles through sequential one-pot Suzuki-Miyaura/Knoevenagel reactions in aqueous medium

Résumé

A series of imidazo[1,2-a]pyridinylpropenenitriles were synthesized via consecutive one-pot Suzuki-Miyaura and Knoevenagel reactions in water/ethanol mixture between imidazo[1,2-a]pyridine-2-carbaldehydes, arylboronic acids and malononitrile, methyl cyanoacetate or ethyl cyanoacetate. This environmental friendly procedure tolerates a wide range of boronic acids and affords a new substituted imidazo[1,2-a]pyridinyl propenenitriles in good yields under microwave irradiation. [GRAPHICS] .

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Dates et versions

hal-02491577 , version 1 (26-02-2020)

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Saleha Bakhta, Youssef Kabri, Maxime D. Crozet, Bellara Nedjar-Kolli, Patrice Vanelle. Synthesis of new substituted imidazo[1,2-a]pyridinylpropenenitriles through sequential one-pot Suzuki-Miyaura/Knoevenagel reactions in aqueous medium. Synthetic Communications, 2019, 49 (19), pp.2561--2571. ⟨10.1080/00397911.2019.1634213⟩. ⟨hal-02491577⟩
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