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Article Dans Une Revue Annals of the New York Academy of Sciences Année : 1998

5-HT4 Receptors: Cloning and Expression of New Splice Variants

Résumé

On the basis of differences in the potencies and intrinsic activity of 5-HT4 receptor agonists in different biological models it has been suggested that there is heterogeneity among 5-HT4 receptors. Here, we report the molecular cloning of several 5-HT4 receptor splice variants in mouse, rat, and human brain. Our data suggest that the differences in efficacy of 5-HT4 ligands on 5-HT4 receptor-mediated responses in several tissues is due to differences in coupling efficiency rather than to the presence of different 5-HT4 receptor isoforms.
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hal-02489922 , version 1 (24-02-2020)

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S. Claeysen, Patrick Faye, Michèle Sebben, Sylvie Taviaux, Joël Bockaert, et al.. 5-HT4 Receptors: Cloning and Expression of New Splice Variants. Annals of the New York Academy of Sciences, 1998, 861 (1), pp.49-56. ⟨10.1111/j.1749-6632.1998.tb10172.x⟩. ⟨hal-02489922⟩
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