<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02489415</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-13T18:10:16+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice</title>
            <author role="aut">
              <persName>
                <forename type="first">Tao</forename>
                <surname>Li</surname>
              </persName>
              <idno type="idhal" notation="numeric">762803</idno>
              <idno type="halauthorid" notation="string">472164-762803</idno>
              <idno type="IDREF">https://www.idref.fr/200239260</idno>
              <affiliation ref="#struct-354355"/>
              <affiliation ref="#struct-168965"/>
              <affiliation ref="#struct-344982"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kenan</forename>
                <surname>Li</surname>
              </persName>
              <idno type="halauthorid">1797459-0</idno>
              <affiliation ref="#struct-354355"/>
              <affiliation ref="#struct-168965"/>
              <affiliation ref="#struct-344982"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Shan</forename>
                <surname>Zhang</surname>
              </persName>
              <idno type="halauthorid">1797460-0</idno>
              <affiliation ref="#struct-354355"/>
              <affiliation ref="#struct-168965"/>
              <affiliation ref="#struct-344982"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yafeng</forename>
                <surname>Wang</surname>
              </persName>
              <idno type="halauthorid">1223025-0</idno>
              <affiliation ref="#struct-354355"/>
              <affiliation ref="#struct-168965"/>
              <affiliation ref="#struct-344982"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yiran</forename>
                <surname>Xu</surname>
              </persName>
              <idno type="halauthorid">1183422-0</idno>
              <affiliation ref="#struct-354355"/>
              <affiliation ref="#struct-168965"/>
              <affiliation ref="#struct-344982"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Shane</forename>
                <forename type="middle">J F</forename>
                <surname>Cronin</surname>
              </persName>
              <idno type="halauthorid">1797461-0</idno>
              <affiliation ref="#struct-300748"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yanyan</forename>
                <surname>Sun</surname>
              </persName>
              <idno type="halauthorid">1183420-0</idno>
              <affiliation ref="#struct-354355"/>
              <affiliation ref="#struct-168965"/>
              <affiliation ref="#struct-344982"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yaodong</forename>
                <surname>Zhang</surname>
              </persName>
              <idno type="halauthorid">1377411-0</idno>
              <affiliation ref="#struct-354355"/>
              <affiliation ref="#struct-168965"/>
              <affiliation ref="#struct-344982"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cuicui</forename>
                <surname>Xie</surname>
              </persName>
              <idno type="halauthorid">1183421-0</idno>
              <affiliation ref="#struct-168965"/>
              <affiliation ref="#struct-344982"/>
              <affiliation ref="#struct-302344"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Juan</forename>
                <forename type="middle">Pablo</forename>
                <surname>Rodríguez</surname>
              </persName>
              <email type="md5">d4436a965f8e5ade0a6d38b2fbfe36f0</email>
              <email type="domain">imperial.ac.uk</email>
              <idno type="idhal" notation="numeric">900712</idno>
              <idno type="halauthorid" notation="string">555894-900712</idno>
              <affiliation ref="#struct-344982"/>
              <affiliation ref="#struct-168965"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kai</forename>
                <surname>Zhou</surname>
              </persName>
              <idno type="halauthorid">1183423-0</idno>
              <affiliation ref="#struct-302344"/>
              <affiliation ref="#struct-344982"/>
              <affiliation ref="#struct-168965"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Henrik</forename>
                <surname>Hagberg</surname>
              </persName>
              <idno type="halauthorid">468099-0</idno>
              <affiliation ref="#struct-344982"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Carina</forename>
                <surname>Mallard</surname>
              </persName>
              <email type="md5">153699c2cbc3e2298b5586cb7d05c444</email>
              <email type="domain">neuro.gu.se</email>
              <idno type="idhal" notation="numeric">928970</idno>
              <idno type="halauthorid" notation="string">468098-928970</idno>
              <affiliation ref="#struct-344982"/>
              <affiliation ref="#struct-168965"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Xiaoyang</forename>
                <surname>Wang</surname>
              </persName>
              <idno type="halauthorid">1183425-0</idno>
              <affiliation ref="#struct-168965"/>
              <affiliation ref="#struct-344982"/>
              <affiliation ref="#struct-354355"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Josef</forename>
                <surname>Penninger</surname>
              </persName>
              <idno type="halauthorid">418318-0</idno>
              <affiliation ref="#struct-300748"/>
              <affiliation ref="#struct-366034"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guido</forename>
                <surname>Kroemer</surname>
              </persName>
              <email type="md5">6b79a0f1ef4c9f06fd97a1b366abd8b4</email>
              <email type="domain">orange.fr</email>
              <idno type="idhal" notation="string">guido-kroemer</idno>
              <idno type="idhal" notation="numeric">758378</idno>
              <idno type="halauthorid" notation="string">220747-758378</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9334-4405</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=OU05Q_MAAAAJ</idno>
              <idno type="VIAF">https://viaf.org/viaf/92175128</idno>
              <idno type="ISNI">http://isni.org/isni/0000000066792574</idno>
              <affiliation ref="#struct-542035"/>
              <affiliation ref="#struct-301664"/>
              <affiliation ref="#struct-303171"/>
              <affiliation ref="#struct-156104"/>
              <affiliation ref="#struct-300119"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Klas</forename>
                <surname>Blomgren</surname>
              </persName>
              <email type="md5">71219b20416cf64dbca755972faecb02</email>
              <email type="domain">neuro.gu.se</email>
              <idno type="idhal" notation="numeric">928969</idno>
              <idno type="halauthorid" notation="string">418286-928969</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0476-7271</idno>
              <affiliation ref="#struct-307368"/>
              <affiliation ref="#struct-302344"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Changlian</forename>
                <surname>Zhu</surname>
              </persName>
              <idno type="halauthorid">481671-0</idno>
              <affiliation ref="#struct-354355"/>
              <affiliation ref="#struct-168965"/>
              <affiliation ref="#struct-344982"/>
              <affiliation ref="#struct-307368"/>
              <affiliation ref="#struct-302344"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Sorbonne Université</forename>
                <surname>Gestionnaire HAL 4</surname>
              </persName>
              <email type="md5">b0df5888550d3ab0396b665cb2d17739</email>
              <email type="domain">scd.upmc.fr</email>
            </editor>
            <funder ref="#projanr-44999"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-02-24 14:30:57</date>
              <date type="whenModified">2026-04-20 20:27:17</date>
              <date type="whenReleased">2020-02-26 12:55:23</date>
              <date type="whenProduced">2020</date>
              <date type="whenEndEmbargoed">2020-02-24</date>
              <ref type="file" target="https://hal.sorbonne-universite.fr/hal-02489415v1/document">
                <date notBefore="2020-02-24"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://hal.sorbonne-universite.fr/hal-02489415v1/file/s41419-020-2280-z.pdf" id="file-2489415-2367567">
                <date notBefore="2020-02-24"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992638"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1066187">
                <persName>
                  <forename>Sorbonne Université</forename>
                  <surname>Gestionnaire HAL 4</surname>
                </persName>
                <email type="md5">b0df5888550d3ab0396b665cb2d17739</email>
                <email type="domain">scd.upmc.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02489415</idno>
            <idno type="halUri">https://hal.sorbonne-universite.fr/hal-02489415</idno>
            <idno type="halBibtex">li:hal-02489415</idno>
            <idno type="halRefHtml">&lt;i&gt;Cell Death and Disease&lt;/i&gt;, 2020, 11 (1), pp.77. &lt;a target="_blank" href="https://dx.doi.org/10.1038/s41419-020-2280-z"&gt;&amp;#x27E8;10.1038/s41419-020-2280-z&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Cell Death and Disease, 2020, 11 (1), pp.77. &amp;#x27E8;10.1038/s41419-020-2280-z&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-2489415-2367567"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="EPHE">École Pratique des Hautes Études</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="FNCLCC" corresp="INSERM">UNICANCER</idno>
            <idno type="stamp" n="IGR" corresp="FNCLCC">Institut Gustave Roussy</idno>
            <idno type="stamp" n="CORDELIERS" corresp="SORBONNE-UNIVERSITE">Centre de recherche des Cordeliers</idno>
            <idno type="stamp" n="PSL">Université Paris sciences et lettres</idno>
            <idno type="stamp" n="CHU-UNIV-PARIS5">Les centres hospitaliers de Paris Descartes</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="TEST-DEV">TEST-DEV</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="EPHE-PSL" corresp="PSL">École Pratique des Hautes Études - PSL</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="SUPRA_BIOLOGIE">Biologie hors MNHN &amp; stations</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Tao</forename>
                    <surname>Li</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">762803</idno>
                  <idno type="halauthorid" notation="string">472164-762803</idno>
                  <idno type="IDREF">https://www.idref.fr/200239260</idno>
                  <affiliation ref="#struct-354355"/>
                  <affiliation ref="#struct-168965"/>
                  <affiliation ref="#struct-344982"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kenan</forename>
                    <surname>Li</surname>
                  </persName>
                  <idno type="halauthorid">1797459-0</idno>
                  <affiliation ref="#struct-354355"/>
                  <affiliation ref="#struct-168965"/>
                  <affiliation ref="#struct-344982"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Shan</forename>
                    <surname>Zhang</surname>
                  </persName>
                  <idno type="halauthorid">1797460-0</idno>
                  <affiliation ref="#struct-354355"/>
                  <affiliation ref="#struct-168965"/>
                  <affiliation ref="#struct-344982"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yafeng</forename>
                    <surname>Wang</surname>
                  </persName>
                  <idno type="halauthorid">1223025-0</idno>
                  <affiliation ref="#struct-354355"/>
                  <affiliation ref="#struct-168965"/>
                  <affiliation ref="#struct-344982"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yiran</forename>
                    <surname>Xu</surname>
                  </persName>
                  <idno type="halauthorid">1183422-0</idno>
                  <affiliation ref="#struct-354355"/>
                  <affiliation ref="#struct-168965"/>
                  <affiliation ref="#struct-344982"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Shane</forename>
                    <forename type="middle">J F</forename>
                    <surname>Cronin</surname>
                  </persName>
                  <idno type="halauthorid">1797461-0</idno>
                  <affiliation ref="#struct-300748"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yanyan</forename>
                    <surname>Sun</surname>
                  </persName>
                  <idno type="halauthorid">1183420-0</idno>
                  <affiliation ref="#struct-354355"/>
                  <affiliation ref="#struct-168965"/>
                  <affiliation ref="#struct-344982"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yaodong</forename>
                    <surname>Zhang</surname>
                  </persName>
                  <idno type="halauthorid">1377411-0</idno>
                  <affiliation ref="#struct-354355"/>
                  <affiliation ref="#struct-168965"/>
                  <affiliation ref="#struct-344982"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cuicui</forename>
                    <surname>Xie</surname>
                  </persName>
                  <idno type="halauthorid">1183421-0</idno>
                  <affiliation ref="#struct-168965"/>
                  <affiliation ref="#struct-344982"/>
                  <affiliation ref="#struct-302344"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Juan</forename>
                    <forename type="middle">Pablo</forename>
                    <surname>Rodríguez</surname>
                  </persName>
                  <email type="md5">d4436a965f8e5ade0a6d38b2fbfe36f0</email>
                  <email type="domain">imperial.ac.uk</email>
                  <idno type="idhal" notation="numeric">900712</idno>
                  <idno type="halauthorid" notation="string">555894-900712</idno>
                  <affiliation ref="#struct-344982"/>
                  <affiliation ref="#struct-168965"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kai</forename>
                    <surname>Zhou</surname>
                  </persName>
                  <idno type="halauthorid">1183423-0</idno>
                  <affiliation ref="#struct-302344"/>
                  <affiliation ref="#struct-344982"/>
                  <affiliation ref="#struct-168965"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Henrik</forename>
                    <surname>Hagberg</surname>
                  </persName>
                  <idno type="halauthorid">468099-0</idno>
                  <affiliation ref="#struct-344982"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Carina</forename>
                    <surname>Mallard</surname>
                  </persName>
                  <email type="md5">153699c2cbc3e2298b5586cb7d05c444</email>
                  <email type="domain">neuro.gu.se</email>
                  <idno type="idhal" notation="numeric">928970</idno>
                  <idno type="halauthorid" notation="string">468098-928970</idno>
                  <affiliation ref="#struct-344982"/>
                  <affiliation ref="#struct-168965"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Xiaoyang</forename>
                    <surname>Wang</surname>
                  </persName>
                  <idno type="halauthorid">1183425-0</idno>
                  <affiliation ref="#struct-168965"/>
                  <affiliation ref="#struct-344982"/>
                  <affiliation ref="#struct-354355"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Josef</forename>
                    <surname>Penninger</surname>
                  </persName>
                  <idno type="halauthorid">418318-0</idno>
                  <affiliation ref="#struct-300748"/>
                  <affiliation ref="#struct-366034"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guido</forename>
                    <surname>Kroemer</surname>
                  </persName>
                  <email type="md5">6b79a0f1ef4c9f06fd97a1b366abd8b4</email>
                  <email type="domain">orange.fr</email>
                  <idno type="idhal" notation="string">guido-kroemer</idno>
                  <idno type="idhal" notation="numeric">758378</idno>
                  <idno type="halauthorid" notation="string">220747-758378</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9334-4405</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=OU05Q_MAAAAJ</idno>
                  <idno type="VIAF">https://viaf.org/viaf/92175128</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000066792574</idno>
                  <affiliation ref="#struct-542035"/>
                  <affiliation ref="#struct-301664"/>
                  <affiliation ref="#struct-303171"/>
                  <affiliation ref="#struct-156104"/>
                  <affiliation ref="#struct-300119"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Klas</forename>
                    <surname>Blomgren</surname>
                  </persName>
                  <email type="md5">71219b20416cf64dbca755972faecb02</email>
                  <email type="domain">neuro.gu.se</email>
                  <idno type="idhal" notation="numeric">928969</idno>
                  <idno type="halauthorid" notation="string">418286-928969</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0476-7271</idno>
                  <affiliation ref="#struct-307368"/>
                  <affiliation ref="#struct-302344"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Changlian</forename>
                    <surname>Zhu</surname>
                  </persName>
                  <idno type="halauthorid">481671-0</idno>
                  <affiliation ref="#struct-354355"/>
                  <affiliation ref="#struct-168965"/>
                  <affiliation ref="#struct-344982"/>
                  <affiliation ref="#struct-307368"/>
                  <affiliation ref="#struct-302344"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">108671</idno>
                <idno type="issn">2041-4889</idno>
                <title level="j">Cell Death and Disease</title>
                <imprint>
                  <publisher>Nature Publishing Group</publisher>
                  <biblScope unit="volume">11</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">77</biblScope>
                  <date type="datePub">2020</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/s41419-020-2280-z</idno>
              <idno type="pubmed">32001673</idno>
              <idno type="pubmedcentral">PMC6992638</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.neu.nb">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology</classCode>
              <classCode scheme="halDomain" n="sdv.bbm.gtp">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Apoptosis inducing factor (AIF) has been shown to be a major contributor to neuron loss in the immature brain after hypoxia-ischemia (HI). Indeed, mice bearing a hypomorphic mutation causing reduced AIF expression are protected against neonatal HI. To further investigate the possible molecular mechanisms of this neuroprotection, we generated an AIF knock-in mouse by introduction of a latent transgene coding for flagged AIF protein into the Rosa26 locus, followed by its conditional activation by a ubiquitously expressed Cre recombinase. Such AIF transgenic mice overexpress the pro-apoptotic splice variant of AIF (AIF1) at both the mRNA (5.9 times higher) and protein level (2.4 times higher), but not the brain-specific AIF splice-isoform (AIF2). Excessive AIF did not have any apparent effects on the phenotype or physiological functions of the mice. However, brain injury (both gray and white matter) after neonatal HI was exacerbated in mice overexpressing AIF, coupled to enhanced translocation of mitochondrial AIF to the nucleus as well as enhanced caspase-3 activation in some brain regions, as indicated by immunohistochemistry. Altogether, these findings corroborate earlier studies demonstrating that AIF plays a causal role in neonatal HI brain injury.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-354355" status="VALID">
          <idno type="ROR">https://ror.org/04ypx8c21</idno>
          <orgName>Zhengzhou University</orgName>
          <desc>
            <address>
              <addrLine>No.100 Science Avenue,Zhengzhou City, Henan Province</addrLine>
              <country key="CN"/>
            </address>
            <ref type="url">http://english.zzu.edu.cn/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-168965" status="VALID">
          <orgName>Institute of Neuroscience and Physiology [Göteborg]</orgName>
          <desc>
            <address>
              <addrLine>Box 430, SE-405 30 Göteborg</addrLine>
              <country key="SE"/>
            </address>
            <ref type="url">http://neurophys.gu.se/english</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-344982" status="VALID">
          <orgName>Sahlgrenska Academy at University of Gothenburg [Göteborg]</orgName>
          <desc>
            <address>
              <addrLine>Box 430, SE-40530 Göteborg</addrLine>
              <country key="SE"/>
            </address>
            <ref type="url">http://sahlgrenska.gu.se/english</ref>
          </desc>
          <listRelation>
            <relation active="#struct-302859" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300748" status="VALID">
          <orgName>Austrian Academy of Sciences</orgName>
          <orgName type="acronym">OeAW</orgName>
          <desc>
            <address>
              <addrLine>Doktor-Ignaz-Seipel-Platz 2, 1010 Wien</addrLine>
              <country key="AT"/>
            </address>
            <ref type="url">http://www.oeaw.ac.at</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-302344" status="VALID">
          <idno type="ROR">https://ror.org/056d84691</idno>
          <orgName>Karolinska Institutet = Karolinska Institute [Stockholm]</orgName>
          <desc>
            <address>
              <addrLine>Solnavägen 1, 171 77 SolnaStockholm</addrLine>
              <country key="SE"/>
            </address>
            <ref type="url">http://ki.se</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-366034" status="VALID">
          <idno type="IdRef">028326792</idno>
          <idno type="ISNI">0000000122889830</idno>
          <idno type="ROR">https://ror.org/03rmrcq20</idno>
          <idno type="Wikidata">Q391028</idno>
          <orgName>University of British Columbia [Canada]</orgName>
          <orgName type="acronym">UBC</orgName>
          <date type="start">1908-01-01</date>
          <desc>
            <address>
              <addrLine>Vancouver Campus, 2329 West Mall, Vancouver, BC, V6T 1Z4 / Okanagan Campus, 3333 University Way, Kelowna, BC, V1V 1V7</addrLine>
              <country key="CA"/>
            </address>
            <ref type="url">https://www.ubc.ca</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-542035" status="OLD">
          <idno type="IdRef">158039203</idno>
          <idno type="ISNI">0000 0004 0620 5824 </idno>
          <idno type="RNSR">200716512X</idno>
          <orgName>Centre de Recherche des Cordeliers</orgName>
          <orgName type="acronym">CRC (UMR_S_1138 / U1138)</orgName>
          <date type="start">2018-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>15 rue de l'Ecole de Médecine - Bâtiment B - 75270 Paris Cedex 06</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.crc.jussieu.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-110691" type="direct"/>
            <relation active="#struct-564132" type="indirect"/>
            <relation name="UMR_S_1138" active="#struct-300301" type="direct"/>
            <relation name="UMR_S_1138" active="#struct-301664" type="direct"/>
            <relation name="U1138" active="#struct-303623" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301664" status="OLD">
          <idno type="IdRef">026404788</idno>
          <idno type="ISNI">0000 0001 2188 0914 </idno>
          <idno type="ROR">https://ror.org/0220k9r37</idno>
          <orgName>Université Paris Descartes - Paris 5</orgName>
          <orgName type="acronym">UPD5</orgName>
          <date type="start">1971-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.parisdescartes.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-303171" status="VALID">
          <idno type="IdRef">19077990X</idno>
          <idno type="ROR">https://ror.org/001z21q04</idno>
          <orgName>Université Sorbonne Paris Cité</orgName>
          <orgName type="acronym">USPC</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-156104" status="VALID">
          <idno type="IdRef">026387433</idno>
          <idno type="ROR">https://ror.org/0321g0743</idno>
          <orgName>Institut Gustave Roussy</orgName>
          <orgName type="acronym">IGR</orgName>
          <desc>
            <address>
              <addrLine>114, rue Édouard-Vaillant 94805 Villejuif Cedex -France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.gustaveroussy.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300119" status="VALID">
          <idno type="IdRef">052497380</idno>
          <idno type="ROR">https://ror.org/016vx5156</idno>
          <orgName>Hôpital Européen Georges Pompidou [APHP]</orgName>
          <orgName type="acronym">HEGP</orgName>
          <desc>
            <address>
              <addrLine>20, rue Leblanc, 75015 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://hopital-georgespompidou.aphp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-353414" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-307368" status="VALID">
          <idno type="ROR">https://ror.org/00m8d6786</idno>
          <orgName>Karolinska University Hospital [Stockholm]</orgName>
          <desc>
            <address>
              <addrLine>Huddinge141 86 Stockholm</addrLine>
              <country key="SE"/>
            </address>
            <ref type="url">http://karolinska.se/karolinska-university-hospital/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-302859" status="VALID">
          <idno type="IdRef">026451492</idno>
          <idno type="ISNI">0000 0000 9919 9582</idno>
          <idno type="ROR">https://ror.org/01tm6cn81</idno>
          <idno type="Wikidata">Q371522</idno>
          <orgName>Göteborgs Universitet = University of Gothenburg</orgName>
          <orgName type="acronym">GU</orgName>
          <desc>
            <address>
              <addrLine>Box 100, SE-405 30 Göteborg</addrLine>
              <country key="SE"/>
            </address>
            <ref type="url">http://www.gu.se/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-110691" status="VALID">
          <idno type="IdRef">026375478</idno>
          <idno type="ISNI">0000000121955365</idno>
          <idno type="ROR">https://ror.org/046b3cj80</idno>
          <orgName>École Pratique des Hautes Études</orgName>
          <orgName type="acronym">EPHE</orgName>
          <date type="start">1868-01-01</date>
          <desc>
            <address>
              <addrLine>4-14 Rue Ferrus, 75014 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ephe.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-564132" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-564132" status="VALID">
          <idno type="IdRef">241597595</idno>
          <idno type="ISNI">0000 0004 1784 3645</idno>
          <idno type="ROR">https://ror.org/013cjyk83</idno>
          <orgName>Université Paris Sciences et Lettres</orgName>
          <orgName type="acronym">PSL</orgName>
          <desc>
            <address>
              <addrLine>60 rue Mazarine 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.psl.eu/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300301" status="OLD">
          <idno type="IdRef">027542084</idno>
          <idno type="ISNI">0000000121514068</idno>
          <idno type="ROR">https://ror.org/02n7qrg46</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-353414" status="VALID">
          <orgName>Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest</orgName>
          <orgName type="acronym">HUPO</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://hopitaux-parisouest.aphp.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-44999" status="VALID">
          <idno type="anr">ANR-16-ECVD-0008</idno>
          <orgName>MINOTAUR</orgName>
          <desc>Metabolic Therapy for Managing Diastolic Heart Failure</desc>
          <date type="start">2016</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>