BIOMIMETIC IONIC MICROSTIMULATION FOR NEURON CULTURE
Résumé
Here, we propose a novel microfluidic system to investigate the response of the neurons directly stimulated by the potassium ions in vitro. Unlike the conventional way of stimulating neurons by pipetting or sending electrical stimulus, this biomimetic stimulation system enables precise and rapid control of ion concentration by utilizing microfluidic pneumatic valves, which mimics physiological stimulation in a body. By using the system, we demonstrated stimulations of the neuron cells with potassium ions and monitored neural activities with a calcium-specific fluorescence indicator.
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