Grey matter density changes of structures involved in Posttraumatic Stress Disorder (PTSD) after recovery following Eye Movement Desensitization and Reprocessing (EMDR) therapy - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Psychiatry Research: Neuroimaging Année : 2017

Grey matter density changes of structures involved in Posttraumatic Stress Disorder (PTSD) after recovery following Eye Movement Desensitization and Reprocessing (EMDR) therapy

Jacques Roques
  • Fonction : Auteur
Nathalie Castelli
  • Fonction : Auteur
Nadia Correard
  • Fonction : Auteur
Aïda Cancel

Résumé

Recovery of stress-induced structural alterations in Posttraumatic Stress Disorder (PTSD) remains largely unexplored. This study aimed to determine whether symptoms improvement is associated with GM density changes of brain structures involved in PTSD. Two groups of PTSD patients were involved in this study. The first group was treated with Eye Movement Desensitization and Reprocessing (EMDR) therapy and recovered from their symptoms (recovery group) (n = 11); Patients were scanned prior to therapy (T1), one week (T2) and five months after the end of therapy (T3). The second group included patients which followed a supportive therapy and remained symptomatic (wait-list group) (n = 7). They were scanned at three time-steps mimicking the same inter-scan intervals. T1-weighted images of anatomical structure were acquired using magnetic resonance imaging (MRI) prior to therapy (T1). Voxel-based morphometry (VBM) was used to characterize GM density evolution. GM density values showed a significant group-by-time interaction effect between T1 and T3 in prefrontal cortex areas. These interaction effects were driven by a GM density increase in the recovery group with respect to the wait-list group. Symptoms removal goes hand-in-hand with GM density enhancement of structures involved in emotional regulation.
Fichier principal
Vignette du fichier
Grey matter density... .pdf (975.05 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02479828 , version 1 (06-04-2020)

Identifiants

Citer

Sarah Boukezzi, Myriam El Khoury-Malhame, Guillaume Auzias, Emmanuelle Reynaud, Pierre-François Rousseau, et al.. Grey matter density changes of structures involved in Posttraumatic Stress Disorder (PTSD) after recovery following Eye Movement Desensitization and Reprocessing (EMDR) therapy. Psychiatry Research: Neuroimaging, 2017, 266, pp.146-152. ⟨10.1016/j.pscychresns.2017.06.009⟩. ⟨hal-02479828⟩

Collections

CNRS UNIV-AMU INT
114 Consultations
459 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More