<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02476814</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-26T14:43:08+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">The health status alters the pituitary function and reproduction of mice in a Cxcr2 -dependent manner</title>
            <author role="aut">
              <persName>
                <forename type="first">Colin</forename>
                <surname>Timaxian</surname>
              </persName>
              <idno type="halauthorid">1791867-0</idno>
              <affiliation ref="#struct-562740"/>
              <affiliation ref="#struct-552459"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Isabelle</forename>
                <surname>Raymond-Letron</surname>
              </persName>
              <idno type="halauthorid">409243-0</idno>
              <affiliation ref="#struct-518989"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Céline</forename>
                <surname>Bouclier</surname>
              </persName>
              <idno type="halauthorid">235635-0</idno>
              <affiliation ref="#struct-562740"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Linda</forename>
                <surname>Gulliver</surname>
              </persName>
              <idno type="idhal" notation="numeric">1515275</idno>
              <idno type="halauthorid" notation="string">1050557-1515275</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9887-1602</idno>
              <affiliation ref="#struct-416928"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ludovic</forename>
                <surname>Le Corre</surname>
              </persName>
              <email type="md5">dc930a3fc2f045c70caad3d80054fc24</email>
              <email type="domain">u-bourgogne.fr</email>
              <idno type="idhal" notation="string">ludovic-le-corre</idno>
              <idno type="idhal" notation="numeric">173318</idno>
              <idno type="halauthorid" notation="string">36432-173318</idno>
              <idno type="IDREF">https://www.idref.fr/095868631</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9127-8881</idno>
              <affiliation ref="#struct-196174"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Karim</forename>
                <surname>Chébli</surname>
              </persName>
              <email type="md5">e2e1168237312104c5dd50431c549012</email>
              <email type="domain">umontpellier.fr</email>
              <idno type="idhal" notation="numeric">759437</idno>
              <idno type="halauthorid" notation="string">524481-759437</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0103-7783</idno>
              <affiliation ref="#struct-712"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne</forename>
                <surname>Guillou</surname>
              </persName>
              <idno type="halauthorid">52547-0</idno>
              <affiliation ref="#struct-1087315"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Patrice</forename>
                <surname>Mollard</surname>
              </persName>
              <email type="md5">e2e500948a10c1916e662546d2f9bfe8</email>
              <email type="domain">igf.cnrs.fr</email>
              <idno type="idhal" notation="string">patrice-mollard</idno>
              <idno type="idhal" notation="numeric">741930</idno>
              <idno type="halauthorid" notation="string">8521-741930</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2324-7589</idno>
              <idno type="IDREF">https://www.idref.fr/068991754</idno>
              <affiliation ref="#struct-1087315"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Karl</forename>
                <surname>Balabanian</surname>
              </persName>
              <idno type="idhal" notation="numeric">758459</idno>
              <idno type="halauthorid" notation="string">222818-758459</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0534-3198</idno>
              <idno type="IDREF">https://www.idref.fr/156891492</idno>
              <affiliation ref="#struct-552459"/>
              <affiliation ref="#struct-1004944"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gwendal</forename>
                <surname>Lazennec</surname>
              </persName>
              <email type="md5">3ad4580d6e7d4a81ee5a59043823c35d</email>
              <email type="domain">sys2diag.cnrs.fr</email>
              <idno type="idhal" notation="string">gwendal-lazennec</idno>
              <idno type="idhal" notation="numeric">738811</idno>
              <idno type="halauthorid" notation="string">45069-738811</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8522-1763</idno>
              <idno type="IDREF">https://www.idref.fr/078635039</idno>
              <affiliation ref="#struct-804"/>
              <affiliation ref="#struct-562740"/>
              <affiliation ref="#struct-552459"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Gwendal</forename>
                <surname>Lazennec</surname>
              </persName>
              <email type="md5">3ad4580d6e7d4a81ee5a59043823c35d</email>
              <email type="domain">sys2diag.cnrs.fr</email>
            </editor>
            <funder ref="#projanr-43101"/>
            <funder>Association pour la Recherche sur le Cancer (ARC) Foundation and la Ligue contre le Cancer</funder>
            <funder>17-CE14-0019, Agence Nationale de la Recherche</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-11-12 13:47:56</date>
              <date type="whenModified">2026-04-02 16:26:19</date>
              <date type="whenReleased">2020-11-12 17:35:08</date>
              <date type="whenProduced">2020-03</date>
              <date type="whenEndEmbargoed">2020-11-12</date>
              <ref type="file" target="https://hal.science/hal-02476814v1/document">
                <date notBefore="2020-11-12"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-02476814v1/file/LSA-2019-00599-TRR_Merged_PDF.pdf" id="file-3001511-2643772">
                <date notBefore="2020-11-12"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010316"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="118109">
                <persName>
                  <forename>Gwendal</forename>
                  <surname>Lazennec</surname>
                </persName>
                <email type="md5">3ad4580d6e7d4a81ee5a59043823c35d</email>
                <email type="domain">sys2diag.cnrs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02476814</idno>
            <idno type="halUri">https://hal.science/hal-02476814</idno>
            <idno type="halBibtex">timaxian:hal-02476814</idno>
            <idno type="halRefHtml">&lt;i&gt;Life Science Alliance&lt;/i&gt;, 2020, 3 (3), pp.e201900599. &lt;a target="_blank" href="https://dx.doi.org/10.26508/lsa.201900599"&gt;&amp;#x27E8;10.26508/lsa.201900599&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Life Science Alliance, 2020, 3 (3), pp.e201900599. &amp;#x27E8;10.26508/lsa.201900599&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3001511-2643772"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
            <idno type="stamp" n="PRES_CLERMONT">Université de Clermont</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-CLERMONT1" corresp="PRES_CLERMONT">Université d'Auvergne - Clermont-Ferrand I</idno>
            <idno type="stamp" n="IGMM">Institut de génétique moléculaire de Montpellier</idno>
            <idno type="stamp" n="IGF">Institut de génomique fonctionnelle</idno>
            <idno type="stamp" n="IGDR">Institut Génétique et Développement de Rennes</idno>
            <idno type="stamp" n="ACL-SVSAE" corresp="PRES_CLERMONT">ACL en SVSAE</idno>
            <idno type="stamp" n="UR1-UFR-SVE">UFR SVE Sciences de la vie et de l'environnement</idno>
            <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno>
            <idno type="stamp" n="UR1-SDV">UR1 - publications SDV</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="BS">Biologie-Santé</idno>
            <idno type="stamp" n="AGROSUP-DIJON">AGROSUP-DIJON</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="TEST-UR-CSS">TEST Université de Rennes CSS</idno>
            <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno>
            <idno type="stamp" n="SYS2DIAG">Modélisation et ingénierie des systèmes complexes biologiques pour le diagnostic</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="UR1-BIO-SA">Pôle UnivRennes - Biologie-Santé</idno>
            <idno type="stamp" n="TOULOUSE-INP">Toulouse - INP</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
            <idno type="stamp" n="ENVT">École Nationale Vétérinaire de Toulouse </idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">The health status alters the pituitary function and reproduction of mice in a Cxcr2 -dependent manner</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Colin</forename>
                    <surname>Timaxian</surname>
                  </persName>
                  <idno type="halauthorid">1791867-0</idno>
                  <affiliation ref="#struct-562740"/>
                  <affiliation ref="#struct-552459"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Isabelle</forename>
                    <surname>Raymond-Letron</surname>
                  </persName>
                  <idno type="halauthorid">409243-0</idno>
                  <affiliation ref="#struct-518989"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Céline</forename>
                    <surname>Bouclier</surname>
                  </persName>
                  <idno type="halauthorid">235635-0</idno>
                  <affiliation ref="#struct-562740"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Linda</forename>
                    <surname>Gulliver</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1515275</idno>
                  <idno type="halauthorid" notation="string">1050557-1515275</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9887-1602</idno>
                  <affiliation ref="#struct-416928"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ludovic</forename>
                    <surname>Le Corre</surname>
                  </persName>
                  <email type="md5">dc930a3fc2f045c70caad3d80054fc24</email>
                  <email type="domain">u-bourgogne.fr</email>
                  <idno type="idhal" notation="string">ludovic-le-corre</idno>
                  <idno type="idhal" notation="numeric">173318</idno>
                  <idno type="halauthorid" notation="string">36432-173318</idno>
                  <idno type="IDREF">https://www.idref.fr/095868631</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9127-8881</idno>
                  <affiliation ref="#struct-196174"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Karim</forename>
                    <surname>Chébli</surname>
                  </persName>
                  <email type="md5">e2e1168237312104c5dd50431c549012</email>
                  <email type="domain">umontpellier.fr</email>
                  <idno type="idhal" notation="numeric">759437</idno>
                  <idno type="halauthorid" notation="string">524481-759437</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0103-7783</idno>
                  <affiliation ref="#struct-712"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne</forename>
                    <surname>Guillou</surname>
                  </persName>
                  <idno type="halauthorid">52547-0</idno>
                  <affiliation ref="#struct-1087315"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Patrice</forename>
                    <surname>Mollard</surname>
                  </persName>
                  <email type="md5">e2e500948a10c1916e662546d2f9bfe8</email>
                  <email type="domain">igf.cnrs.fr</email>
                  <idno type="idhal" notation="string">patrice-mollard</idno>
                  <idno type="idhal" notation="numeric">741930</idno>
                  <idno type="halauthorid" notation="string">8521-741930</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2324-7589</idno>
                  <idno type="IDREF">https://www.idref.fr/068991754</idno>
                  <affiliation ref="#struct-1087315"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Karl</forename>
                    <surname>Balabanian</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">758459</idno>
                  <idno type="halauthorid" notation="string">222818-758459</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0534-3198</idno>
                  <idno type="IDREF">https://www.idref.fr/156891492</idno>
                  <affiliation ref="#struct-552459"/>
                  <affiliation ref="#struct-1004944"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gwendal</forename>
                    <surname>Lazennec</surname>
                  </persName>
                  <email type="md5">3ad4580d6e7d4a81ee5a59043823c35d</email>
                  <email type="domain">sys2diag.cnrs.fr</email>
                  <idno type="idhal" notation="string">gwendal-lazennec</idno>
                  <idno type="idhal" notation="numeric">738811</idno>
                  <idno type="halauthorid" notation="string">45069-738811</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8522-1763</idno>
                  <idno type="IDREF">https://www.idref.fr/078635039</idno>
                  <affiliation ref="#struct-804"/>
                  <affiliation ref="#struct-562740"/>
                  <affiliation ref="#struct-552459"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">132334</idno>
                <idno type="issn">2575-1077</idno>
                <title level="j">Life Science Alliance</title>
                <imprint>
                  <publisher>Life Science Alliance LLC</publisher>
                  <biblScope unit="volume">3</biblScope>
                  <biblScope unit="issue">3</biblScope>
                  <biblScope unit="pp">e201900599</biblScope>
                  <date type="datePub">2020-03</date>
                  <date type="dateEpub">2020-02-10</date>
                </imprint>
              </monogr>
              <idno type="doi">10.26508/lsa.201900599</idno>
              <idno type="pubmed">32041848</idno>
              <idno type="pubmedcentral">PMC7010316</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">pituitary</term>
                <term xml:lang="en">Cxcr2</term>
                <term xml:lang="en">microbiota</term>
                <term xml:lang="en">cytokines</term>
                <term xml:lang="en">chemokine receptors</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.ba.mvsa">Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.mi">Life Sciences [q-bio]/Human health and pathology/Infectious diseases</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.em">Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism</classCode>
              <classCode scheme="halDomain" n="sdv.bdlr.rs">Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Microbiota and chronic infections can affect not only immune status, but also the overall physiology of animals. Here, we report that chronic infections dramatically modify the phenotype of Cxcr2 KO mice, impairing in particular, their reproduction ability. We show that exposure of Cxcr2 KO females to multiple types of chronic infections prevents their ability to cycle, reduces the development of the mammary gland and alters the morphology of the uterus due to an impairment of ovary function. Mammary gland and ovary transplantation demonstrated that the hormonal contexture was playing a crucial role in this phenomenon. This was further evidenced by alterations to circulating levels of sex steroid and pituitary hormones. By analyzing at the molecular level the mechanisms of pituitary dysfunction, we showed that in the absence of Cxcr2, bystander infections affect leukocyte migration, adhesion, and function, as well as ion transport, synaptic function behavior, and reproduction pathways. Taken together, these data reveal that a chemokine receptor plays a direct role in pituitary function and reproduction in the context of chronic infections.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-562740" status="VALID">
          <idno type="RNSR">200919301V</idno>
          <idno type="ROR">056mmjd70</idno>
          <orgName>Sys2Diag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic</orgName>
          <orgName type="acronym">Sys2Diag</orgName>
          <date type="start">2017-01-01</date>
          <desc>
            <address>
              <addrLine>CAP DELTA - 1682 RUE DE LA VALSIERE34184 MONTPELLIER CEDEX 4</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.sys2diag.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR9005" active="#struct-441569" type="direct"/>
            <relation active="#struct-562738" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-552459" status="VALID">
          <orgName>Microenvironnement des niches tumorales</orgName>
          <orgName type="acronym">CNRS GDR 3697 Micronit</orgName>
          <desc>
            <address>
              <addrLine>Cancéropôle Grand Ouest3 Chaussée de la Madeleine44000 NANTES</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://cancer-niches-cgo.fr/index.php</ref>
          </desc>
          <listRelation>
            <relation active="#struct-303623" type="direct"/>
            <relation name="CNRS GDR 3697" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-518989" status="OLD">
          <idno type="IdRef">240566181</idno>
          <idno type="ISNI">0000 0004 7669 0415</idno>
          <idno type="RNSR">201119470V</idno>
          <idno type="ROR">https://ror.org/01tfttw56</idno>
          <orgName>STROMALab</orgName>
          <date type="start">2011-01-01</date>
          <date type="end">2020-12-31</date>
          <desc>
            <address>
              <addrLine>Bâtiment INCERE4bis avenue Hubert CURIEN31100 TOULOUSE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.stromalab.fr/fr/</ref>
          </desc>
          <listRelation>
            <relation name="UM100" active="#struct-199980" type="direct"/>
            <relation name="UMR5273" active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-300421" type="direct"/>
            <relation active="#struct-448187" type="indirect"/>
            <relation name="U1031" active="#struct-303623" type="direct"/>
            <relation name="ERL5311" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-416928" status="VALID">
          <idno type="IdRef">034371362</idno>
          <orgName>University of Otago [Dunedin, Nouvelle-Zélande]</orgName>
          <date type="start">1869</date>
          <desc>
            <address>
              <addrLine>362 Leith St, North Dunedin, Dunedin 9016, New-Zeland</addrLine>
              <country key="NZ"/>
            </address>
            <ref type="url">https://www.otago.ac.nz/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-196174" status="VALID">
          <orgName>Nutrition, Cancérogenèse et Thérapie anti-tumorale</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="EA4233" active="#struct-300267" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-712" status="OLD">
          <idno type="ISNI">0000000405990285</idno>
          <idno type="RNSR">199111979P</idno>
          <idno type="ROR">https://ror.org/02785qs39</idno>
          <orgName>Institut de Génétique Moléculaire de Montpellier</orgName>
          <orgName type="acronym">IGMM</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1919 Route de Mende - 34293 Montpellier Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.igmm.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-410122" type="direct"/>
            <relation name="UMR5535 / UMR9942" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1087315" status="OLD">
          <idno type="ISNI">0000000403832080</idno>
          <idno type="RNSR">200717476V</idno>
          <idno type="ROR">https://ror.org/043wmc583</idno>
          <orgName>Institut de Génomique Fonctionnelle</orgName>
          <orgName type="acronym">IGF</orgName>
          <date type="start">2015-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>141, Rue de la Cardonille 34094 Montpellier cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.igf.cnrs.fr</ref>
          </desc>
          <listRelation>
            <relation name="U1191" active="#struct-303623" type="direct"/>
            <relation active="#struct-410122" type="direct"/>
            <relation name="UMR5203" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1004944" status="OLD">
          <idno type="RNSR">201420725W</idno>
          <orgName>Ecotaxie, microenvironnement et développement lymphocytaire</orgName>
          <orgName type="acronym">EMily (UMR_S_1160 / U1160)</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>Hôpital Saint-Louis, 1 avenue Claude Vellfaux, IUH, Centre Georges Hayem, 75010 PARIS</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.Inserm-umrs1160.com/</ref>
          </desc>
          <listRelation>
            <relation name="U1160" active="#struct-303623" type="direct"/>
            <relation name="UMR_S_1160" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-804" status="OLD">
          <orgName>Interactions cellulaires et moléculaires</orgName>
          <orgName type="acronym">ICM</orgName>
          <date type="start">2000-01-01</date>
          <date type="end">2011-12-31</date>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu, 263 avenue du Général Leclerc CS 74205 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://umr6026.univ-rennes1.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation name="UMR6026" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-562738" status="VALID">
          <orgName>Alcediag</orgName>
          <desc>
            <address>
              <addrLine>Parc EuromedecineCAP DELTA - 1682 RUE DE LA VALSIERE 34184 MONTPELLIER CEDEX 4</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.alcediag-alcen.com/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-199980" status="VALID">
          <orgName>Établissement Français du Sang [La Plaine Saint-Denis]</orgName>
          <orgName type="acronym">EFS</orgName>
          <date type="start">2000-01-01</date>
          <desc>
            <address>
              <addrLine>20 Avenue du Stade de France 93218 La Plaine Saint Denis</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.dondusang.net</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-300421" status="VALID">
          <idno type="ROR">https://ror.org/03m3gzv89</idno>
          <orgName>École nationale vétérinaire de Toulouse</orgName>
          <orgName type="acronym">ENVT</orgName>
          <desc>
            <address>
              <addrLine>23 chemin des Capelles - 31076 Toulouse Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://envt.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-448187" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-448187" status="VALID">
          <idno type="IdRef">026388820</idno>
          <idno type="ISNI">0000000121766169</idno>
          <idno type="ROR">https://ror.org/033p9g875</idno>
          <orgName>Institut National Polytechnique (Toulouse)</orgName>
          <orgName type="acronym">Toulouse INP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.inp-toulouse.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300267" status="OLD">
          <orgName>Université d'Auvergne - Clermont-Ferrand I</orgName>
          <orgName type="acronym">UdA</orgName>
          <date type="end">2016-12-31</date>
          <desc>
            <address>
              <addrLine>49, Boulevard François-Mitterrand / CS 60032 / 63001 Clermont-Ferrand Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-clermont1.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-410122" status="OLD">
          <idno type="ISNI">0000000120970141</idno>
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-105160" status="VALID">
          <idno type="IdRef">26693823X</idno>
          <idno type="ROR">https://ror.org/015m7wh34</idno>
          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UR</orgName>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu, 263 avenue Général Leclerc, CS 74205, 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-rennes.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-43101" status="VALID">
          <idno type="anr">ANR-17-CE14-0019</idno>
          <orgName>OSTEOVALYMPH</orgName>
          <desc>Autocrinie et paracrinie de l'axe de signalisation CXCL12/CXCR4-CXCR7 dans la niche ostéo-vasculaire: impact sur la spécification et l'engagement lymphoïde des cellules souches hématopoïétiques</desc>
          <date type="start">2017</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>