Effect of secondary polymer on self‐precipitation of pH‐sensitive polymethylmethacrylate derivatives Eudragit E100 and Eudragit L100 - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Polymers for Advanced Technologies Année : 2020

Effect of secondary polymer on self‐precipitation of pH‐sensitive polymethylmethacrylate derivatives Eudragit E100 and Eudragit L100

Résumé

Interpolyelectrolyte complexes or polyplexes can be seen as interesting alternatives in the purpose of active ingredients encapsulation. Working on polymethylmethacrylate derivatives with special focus on controlled oral drug delivery, the influence of charged polyelectrolytes (polyacrylic acid, polyethylenimine, amino-dextran) and non-charged ones (polyvinyl alcohol , dextran 40, Pluronic F68) has been investigated on the precipitation of two pH-sensitive Eudragit polymers namely L100 and E100. Moreover, the possibility of preparing polyplexes involving the two polymethylmethacrylate derivatives with different charged and non-charged secondary polyelectrolytes has been studied. The obtained dispersions have been characterized in terms of mean particle size, size distribution, zeta potential and morphology. Direct precipitation of Eudragit L100 by medium acidification in a batch process and in presence of polyethylenimine allowed the production of particles with a narrow size distribution. The mean size was around 200 nm. In this case, the zeta potential was found to be +45 mV at pH=7 in 1 mM aqueous NaCl solution and the produced suspension was stable in time since no aggregation and then no sedimentation has been observed. A precipitation pH of 8.16 allows us to suggest the preparation of a polyplex based on Eudragit L100 and polyethylenimine. In contrary, polyvinyl alcohol has shown ability to induce an increase in * .
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Dates et versions

hal-02475657 , version 1 (17-11-2020)

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Fabrice Ofridam, Noureddine Lebaz, Emilie Gagniere, Denis Mangin, Abdelhamid Elaissari. Effect of secondary polymer on self‐precipitation of pH‐sensitive polymethylmethacrylate derivatives Eudragit E100 and Eudragit L100. Polymers for Advanced Technologies, 2020, 31 (6), ⟨10.1002/pat.4856⟩. ⟨hal-02475657⟩
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