An oxidatively damaged G-quadruplex/hemin DNAzyme
Résumé
Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-quadruplex/hemin DNAzyme activity and provides clues to the mechanistic origins of DNAzyme deactivation, which originates from an interplay between decreased G-quadruplex stability, lower hemin affinity and a modification of the nature of hemin binding sites.
Domaines
Biochimie [q-bio.BM]
Origine : Fichiers produits par l'(les) auteur(s)
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