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Poster De Conférence Année : 2020

Non-cell autonomous roles of telomere shortening in zebrafish

Gil Mariana
  • Fonction : Auteur
Margarida Figueira
  • Fonction : Auteur
Miguel G. Ferreira
Mariana M Gil
  • Fonction : Auteur
Naz Serifoglu
  • Fonction : Auteur
Margarida Figueira
  • Fonction : Auteur
Miguel Godinho Ferreira
  • Fonction : Auteur

Résumé

Background: Cancer incidence increases with age. Due to the end-replicative problem, telomeres shorten with each cell division throughout our lives. Telomere shortening has consequences beyond the cellular level. As we age, cells approach replicative senescence and DNA damage emanating by short telomeres initiate a cascade of events that expands to the extracellular environment. Senescent cells were shown to release a set of molecules including inflammatory cytokines, termed senescence-associated secretory phenotype (SASP). Indeed, an inflammatory environment generates a pro-tumorigenic environment that supports tumor invasiveness. Aim of the study: Investigate the causal relation between short telomeres and cancer incidence. Determine whether this effect has a non-cell autonomous component by using zebrafish embryo chimeras and tumor transplants.
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Dates et versions

hal-02472505 , version 1 (02-12-2020)

Identifiants

Citer

Gil Mariana, Margarida Figueira, Miguel G. Ferreira, Mariana M Gil, Ahmed Maouche, et al.. Non-cell autonomous roles of telomere shortening in zebrafish. 4th Labex SIGNALIFE Meeting, Feb 2020, Nice, France. 2020, ⟨10.1073/pnas.1920049117/-/DCSupplemental.www.pnas.org/cgi/doi/10.1073/pnas.1920049117⟩. ⟨hal-02472505⟩
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