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                <term xml:lang="en">Nervous system disorders</term>
                <term xml:lang="en">Beds</term>
                <term xml:lang="en">Demography</term>
                <term xml:lang="en">Health personnel</term>
                <term xml:lang="en">health insurance</term>
                <term xml:lang="en">Health services</term>
                <term xml:lang="en">Multiple sclerosis</term>
                <term xml:lang="en">Physicians</term>
                <term xml:lang="en">Family</term>
                <term xml:lang="en">Socioeconomic factors</term>
                <term xml:lang="en">Urbanization</term>
                <term xml:lang="en">Disease management</term>
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                <term xml:lang="en">Neurologists</term>
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              <p>Background: Multiple sclerosis (MS) is a chronic neurological disease affecting about 100,000 persons in France. Disease management is mainly supervised by the neurologist, supported by the general practitioner (GP). The complexity of the disease, due to the variety of symptoms as well as the recent changes in the therapeutic arsenal, requires both a high level of expertise and coordination between the different health care providers. To face this challenge, integrated and coordinated network of services “MS expert centers” have been progressively set up from 2000 onwards. Our objectives are to describe referrals to MS expert centers over the 2010-2015 period, to look for geographic variations and if any, to identify potential determinants of access.MethodsThe analysis is performed on the French health insurance database which covers 97% of the French population. Geographic variations of access are explored, as well as association with the following parameters: demographics (age, sex), socio-economic characteristics (social deprivation index at residence, degree of urbanization), and density of health care services (GPs, neurologists, hospital beds).ResultsOverall, 112,415 people with MS (70% women, mean age 46 years) were included. Initial results show that over the study period, 98% of patient had at least one visit to GP, 87% to neurologist, and 36% in a CRC SEP.ConclusionsThe present study will assess to what extent MS patients have been able to take full advantage of an innovative organization of specialized care which was recently deployed in France. This model of care has been generalized by the French Ministry of Health in 2016 and 23 ‘competence and resource centers’ for MS (CRC SEP) are now covering the whole national territory. Further research will be performed to identify whether and how this has modified access to specialized coordinated MS care.</p>
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