Calcium-independent disruption of microtubule growth following nanosecond pulsed electric field exposure in U87 human glioblastoma cells
Résumé
Nanosecond pulsed electric field (nsPEF) exposure causes apoptosis in cancer cells via a currently unknown mechanism. Weused liv e cell imaging to show that 100, 10 ns, 15 kV/cm pulses, applied at 10 Hz to U87 EB3-GFP glioblastoma cells, results in calcium-independent disruption of microtubule growth. Microtubule depolymerization is a key event in apoptosis
execution, making the effect we report on the microtubule network a candidate for the mechanism behind nsPEF induced
apoptosis.
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