Numerous studies have confirmed that Alzheimer’s patients may benefit from memory rehabilitation processes. In this context, we propose a non pharmacological training, named Autobiographical Training. It is an adaptive and accessible “Question/Answer” training. It has a purpose to stimulate the patient’s memory. It is proposed in the context of a memory prosthesis called Captain Memo. (1) Autobiographical Training do not use general facts or false examples, but it automatically propose for each user their specific questions related to his life e.g., events that he lived. (2) It adjusts automatically the level of difficulty of the generated question depending on the progression of Alzheimer’s disease. (3) It supports multilingualism and multiculturalism. (4) It offers accessible user interfaces. We evaluated the accessibility and the usability of Autobiographical Training. 18 participants entered the study. The results confirmed that it is accessible and the frequent use of this training helps patients in reminding some information, in which they received the training.