Structure and engineering of tandem repeat lectins - Archive ouverte HAL Access content directly
Journal Articles Current Opinion in Structural Biology Year : 2020

Structure and engineering of tandem repeat lectins


(100 − 120 words) Through their ability to bind complex glycoconjugates, lectins have unique specificity and potential for biomedical and biotechnological applications. In particular, lectins with short repeated peptides forming carbohydrate-binding domains are not only of high interest for understanding protein evolution but can also be used as scaffold for engineering novel receptors. Synthetic glycobiology now provides the tools for engineering the specificity of lectins as well as their structure, multivalency and topologies. This review focuses on the structure and diversity of two families of tandem-repeat lectins, i.e. β-trefoils and β-propellers, demonstrated as the most promising scaffold for engineering novel lectins.
Fichier principal
Vignette du fichier
tandem_repeat_hal.pdf (1.47 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-02463790 , version 1 (01-02-2020)



Simona Notova, François Bonnardel, Frédérique Lisacek, Annabelle Varrot, Anne Imberty. Structure and engineering of tandem repeat lectins. Current Opinion in Structural Biology, 2020, 62, pp.39-47. ⟨10.1016/⟩. ⟨hal-02463790⟩
88 View
124 Download



Gmail Facebook Twitter LinkedIn More