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            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
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                <term xml:lang="en">chiral ionic liquid</term>
                <term xml:lang="en">binaphthol derivatives</term>
                <term xml:lang="en">capillary electrophoresis</term>
                <term xml:lang="en">enantioseparation</term>
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              <p>Chiral binaphthols belong to the group of most effective ligands for asymmetrical catalysis. In  this context, various binaphthols presenting original substituents have been synthesized. Their  study through capillary electrophoresis is the object of this work. The literature dedicated to the separation of atropisomers by capillary electrophoresis, corresponding only to binaphthol,  reveals that its enantioseparation is always delicate because of the influence of many factors  and the resolutions obtained are weak. Therefore, for a structured optimization, we first successfully evaluated the acidity constants of different binaphthols by means of capillary  electrophoresis. With these known physicochemical characteristics, we could successfully  carry out enantiomeric separations of the different binaphthols at pH=11.5, practically in completely ionized form, in phosphate medium, and in the presence of cyclodextrin (CD),  with analysis times lower than 8 minutes. The nature of CDs (α-CD, β-CD, γ-CD, hydroxypropyl-α-cyclodextrin (HP-α-CD), HP-β-CD, HP-γ-CD and trimethyl-β-CD (TM-β- CD)) and other factors in relation to enantiomeric resolution (applied voltage, nature and  concentration of the electrolyte, and concentration of cyclodextrin) were optimized. These studies allowed us to determine the optimal conditions of separation (concentration and nature  of CD) for each of the studied binaphthols. It is necessary to mention that, for the 1,1'-26 binaphthyl-2,2'-diol (Binol) at pH=11.5, the S atropisomer always migrated first, regardless of the nature and concentration of the cyclodextrin used. Moreover, an inversion in elution ordeof the two atropisomers as a function of pH was observed with γ-CD (pH range: 10-11.5). The R atropisomer migrated first at pH=10. At pH=10.8 the migration order of the two  atropisomers of Binol was reversed as a function of γ-CD concentration. Finally, the addition 31 of chiral ionic liquids (R(−)-1-hydroxy-N,N,N-trimethylbutan-2-aminium bis(trifluoromethylsulfonyl)imide and S(+)-tetrabutylammonium camphorsulfonate) was  conducted. In the case of S(+)-tetrabutylammonium camphor-sulfonate, a weak antagonistic  effect was observed with modeling the evolution of enantiomeric resolution by means of the 35 experimental design, while in the case of R(−)-1-hydroxy-N,N,N-trimethylbutan-2-aminium 36 bis(trifluoromethylsulfonyl)imide the effect was neutral.</p>
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