Article Dans Une Revue Obesity Facts Année : 2020

OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions

1 CRNH-RA - Centre de Recherche en Nutrition Humaine Rhône-Alpes
2 UCPH - Københavns Universitet = University of Copenhagen = Université de Copenhague
3 CBMR - Novo Nordisk Foundation Center for Basic Metabolic Research
4 MUMC - Maastricht University Medical Centre
5 CHU Clermont-Ferrand
6 TNO - Netherlands Organization for Applied Scientific Research
7 INSERM - Institut National de la Santé et de la Recherche Médicale
8 UT - Université de Tours
9 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
10 iBraiN - Imaging, Brain & Neuropsychiatry
11 KC Microbiome Communications Group
12 Nutriomics - Nutrition et obésités: approches systémiques (UMR-S 1269)
13 NIHR Biomedical Research Centre [London]
14 CAM - University of Cambridge [Cambridge, UK]
15 UNIGE - Université de Genève = University of Geneva
16 Geneva University Hospitals and Geneva University
17 Clínica Universidad de Navarra [Pamplona]
18 Nestlé Institute of Health Sciences SA [Lausanne, Switzerland]
19 University of Liverpool
20 TUM - Technische Universität Munchen = Technical University Munich = Université Technique de Munich
21 MRI TUM - Klinikum rechts der Isar
22 CNRS - Centre National de la Recherche Scientifique
23 UN - Université de Nantes
24 ITX - ITX - unité de recherche de l'institut du thorax
25 EREN [CRESS - U1153 / UMR_A 1125] - Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle
26 UT3 - Université Toulouse III - Paul Sabatier
27 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
28 UniPi - University of Pisa [Italy] = Università di Pisa [Italia] = Université de Pise [Italie]
29 Karolinska Institutet = Karolinska Institute [Stockholm]
30 CHU Pitié-Salpêtrière [AP-HP]
31 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
32 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna [Bologne]
33 ULISBOA - Universidade de Lisboa = University of Lisbon = Université de Lisbonne [Lisboa]
34 UCD - University College Dublin [Dublin]
35 CHU-Liège - Centre Hospitalier Universitaire de Liège
36 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
37 UNIL - Université de Lausanne = University of Lausanne
38 Minerva Foundation Institute for Medical Research
39 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
40 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
Yves Boirie

Résumé

Heterogeneity of interindividual and intraindividual responses to interventions is often observed in randomized, controlled trials for obesity. To address the global epidemic of obesity and move toward more personalized treatment regimens, the global research community must come together to identify factors that may drive these heterogeneous responses to interventions. This project, called OBEDIS (OBEsity Diverse Interventions Sharing - focusing on dietary and other interventions), provides a set of European guidelines for a minimal set of variables to include in future clinical trials on obesity, regardless of the specific endpoints. Broad adoption of these guidelines will enable researchers to harmonize and merge data from multiple intervention studies, allowing stratification of patients according to precise phenotyping criteria which are measured using standardized methods. In this way, studies across Europe may be pooled for better prediction of individuals' responses to an intervention for obesity - ultimately leading to better patient care and improved obesity outcomes.

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hal-02454906 , version 1 (31-03-2021)

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Maud Alligier, Romain Barrès, Ellen e. Blaak, Yves Boirie, Jildau Bouwman, et al.. OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions. Obesity Facts, 2020, 13 (1), pp.1-28. ⟨10.1159/000505342⟩. ⟨hal-02454906⟩
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