Four monomeric copper( ii ) complexes of non-steroidal anti-inflammatory drug Ibuprofen and N-donor ligands: syntheses, characterization, crystal structures and cytotoxicity studies - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue New Journal of Chemistry Année : 2017

Four monomeric copper( ii ) complexes of non-steroidal anti-inflammatory drug Ibuprofen and N-donor ligands: syntheses, characterization, crystal structures and cytotoxicity studies

Santosh Kumar
  • Fonction : Auteur
Shipra Garg
  • Fonction : Auteur
Raj Pal Sharma
  • Fonction : Auteur
Paloth Venugopalan
  • Fonction : Auteur
Lorenzo Tenti
  • Fonction : Auteur
Valeria Ferretti
  • Fonction : Auteur

Résumé

Reaction of hydrated copper(II) ibuprofenate with various nitrogen donor ligands, β-picoline, γ-picoline, pyrrolidine and unsymetrical dimethyl ethylenediamine (unsym-dmen), at room temperature in a methanol : water mixture (4 : 1 v/v) yielded four new complexes, [Cu(Ibu)2(β-picoline)2(H2O)], 1; [Cu(Ibu)2(γ-picoline)2(H2O)]·H2O, 2; [Cu(Ibu)2(pyrrolidine)2]·H2O, 3; and [Cu(unsym-dmen)2(H2O)](Ibu)2, 4, respectively, where Ibu = deprotonated Ibuprofen (HIbu). The newly synthesized complexes have been characterized by elemental analyses, spectroscopic methods (FT-IR, UV-Vis and EPR), TGA and single crystal X-ray structure determination. Crystallographic investigations revealed that all the complexes are monomeric in nature, in contrast to the dimeric nature of copper(II) ibuprofenate solvates. EPR studies clearly revealed that the chromophore present in all complexes (1–4) is consistent with the structures determined by X-ray crystallography. The cytotoxic effects of all complexes were tested by a colorimetric assay on three human cell lines; though the activity was affected by the nature of the cell line, the newly synthesized complexes 1–4 showed higher cytotoxicity than the parent molecule against all the tumoral cell lines.

Dates et versions

hal-02452836 , version 1 (23-01-2020)

Identifiants

Citer

Santosh Kumar, Shipra Garg, Raj Pal Sharma, Paloth Venugopalan, Lorenzo Tenti, et al.. Four monomeric copper( ii ) complexes of non-steroidal anti-inflammatory drug Ibuprofen and N-donor ligands: syntheses, characterization, crystal structures and cytotoxicity studies. New Journal of Chemistry, 2017, 41 (16), pp.8253-8262. ⟨10.1039/c7nj00247e⟩. ⟨hal-02452836⟩
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