Propensity score analysis confirms the independent effect of parenteral nutrition on the risk of central venous catheter-related bloodstream infection in oncological patients - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Clinical Nutrition Année : 2013

Propensity score analysis confirms the independent effect of parenteral nutrition on the risk of central venous catheter-related bloodstream infection in oncological patients

A. Toure
  • Fonction : Auteur
C. Chambrier
  • Fonction : Auteur
Philippe Vanhems
C. Lombard-Bohas
  • Fonction : Auteur
J. C. Souquet
  • Fonction : Auteur

Résumé

Background & aims: Parenteral nutrition is known as a high-risk factor for central venous catheter-related bloodstream infection (CVC-RBSI) in cancer patients. Owing to ethical and technical problems, the studies in the literature have nonrandomized designs and are therefore often confounded by biases. We performed a propensity score analysis to estimate the effect of parenteral nutrition on CVC-RBSI in digestive cancer patients who underwent chemotherapy. Methods: Data were collected prospectively. A logistic regression model was used to calculate a propensity score, which was the probability of receiving parenteral nutrition. Kaplan-Meier survival and Cox regression model were used to estimate the effect of the parenteral nutrition on CVC-RBSI after adjustment for the propensity score. Results: Before the propensity score analysis, the differences between patients with (n = 113) and without (n = 312) parenteral nutrition were identified including: male gender, body weight, weight loss, performance status, location of primary cancer, FOLFIRI, and previous long-term corticotherapy. After propensity score stratification, all of the covariates were balanced within each stratum. After adjustment, patients with parenteral nutrition were at a higher risk for CVC-RBSI. Conclusion: By using the propensity score analysis, this study confirmed that parenteral nutrition was an independent risk factor for CVC-RBSI in digestive cancer patients.

Dates et versions

hal-02446472 , version 1 (20-01-2020)

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Citer

A. Toure, C. Chambrier, Philippe Vanhems, C. Lombard-Bohas, J. C. Souquet, et al.. Propensity score analysis confirms the independent effect of parenteral nutrition on the risk of central venous catheter-related bloodstream infection in oncological patients. Clinical Nutrition, 2013, 32 (6), pp.1050--4. ⟨10.1016/j.clnu.2012.12.006⟩. ⟨hal-02446472⟩
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