<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02445470</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-19T01:57:02+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">A genome-wide CRISPR-Cas9 screen identifies the dolichol-phosphate mannose synthase complex as a host dependency factor for dengue virus infection</title>
            <author role="aut">
              <persName>
                <forename type="first">Athena</forename>
                <surname>Labeau</surname>
              </persName>
              <idno type="halauthorid">1356610-0</idno>
              <affiliation ref="#struct-1005063"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Etienne</forename>
                <surname>Simon-Loriere</surname>
              </persName>
              <email type="md5">4de6ffa92427a64feed56970e9781af0</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="string">etiennesimon-loriere</idno>
              <idno type="idhal" notation="numeric">734968</idno>
              <idno type="halauthorid" notation="string">19689-734968</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8420-7743</idno>
              <idno type="IDREF">https://www.idref.fr/136869076</idno>
              <affiliation ref="#struct-526159"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mohamed-Lamine</forename>
                <surname>Hafirassou</surname>
              </persName>
              <idno type="halauthorid">1682321-0</idno>
              <affiliation ref="#struct-1005063"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lucie</forename>
                <surname>Bonnet-Madin</surname>
              </persName>
              <idno type="halauthorid">1356611-0</idno>
              <affiliation ref="#struct-1005063"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sarah</forename>
                <surname>Tessier</surname>
              </persName>
              <idno type="halauthorid">1315721-0</idno>
              <affiliation ref="#struct-1005063"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alessia</forename>
                <surname>Zamborlini</surname>
              </persName>
              <email type="md5">08d01298eb798a98a490cafc1ab932d4</email>
              <email type="domain">universite-paris-saclay.fr</email>
              <idno type="idhal" notation="string">alessia-zamborlini</idno>
              <idno type="idhal" notation="numeric">1359625</idno>
              <idno type="halauthorid" notation="string">212254-1359625</idno>
              <idno type="IDREF">https://www.idref.fr/202911039</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=PPu-d5UAAAAJ</idno>
              <affiliation ref="#struct-1005063"/>
              <affiliation ref="#struct-414518"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thierry</forename>
                <surname>Dupré</surname>
              </persName>
              <idno type="halauthorid">375455-0</idno>
              <affiliation ref="#struct-300156"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nathalie</forename>
                <surname>Seta</surname>
              </persName>
              <idno type="halauthorid">252914-0</idno>
              <affiliation ref="#struct-300156"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Schwartz</surname>
              </persName>
              <email type="md5">fe5083020856ea33a909646be8fe5974</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="numeric">999827</idno>
              <idno type="halauthorid" notation="string">217629-999827</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0729-1475</idno>
              <idno type="IDREF">https://www.idref.fr/128673850</idno>
              <affiliation ref="#struct-410873"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Laure</forename>
                <surname>Chaix</surname>
              </persName>
              <idno type="halauthorid">121406-0</idno>
              <affiliation ref="#struct-1005063"/>
              <affiliation ref="#struct-506757"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Constance</forename>
                <surname>Delaugerre</surname>
              </persName>
              <idno type="halauthorid">611839-0</idno>
              <affiliation ref="#struct-1005063"/>
              <affiliation ref="#struct-506757"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Ali</forename>
                <surname>Amara</surname>
              </persName>
              <email type="md5">7df1e5129b50bf2523cfd6c374fb4934</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="numeric">864445</idno>
              <idno type="halauthorid" notation="string">222912-864445</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0283-1815</idno>
              <affiliation ref="#struct-1005063"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Laurent</forename>
                <surname>Meertens</surname>
              </persName>
              <email type="md5">fa00e8c2777218ef9fa650b845af67bb</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="numeric">1057925</idno>
              <idno type="halauthorid" notation="string">555111-1057925</idno>
              <affiliation ref="#struct-1005063"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Isabelle</forename>
                <surname>HUE</surname>
              </persName>
              <email type="md5">e0c7f5a97ee2162a259541b971b2e5f1</email>
              <email type="domain">i2bc.paris-saclay.fr</email>
            </editor>
            <funder ref="#projanr-24021"/>
            <funder ref="#projanr-47681"/>
            <funder>Work in A.A.’s lab has received funding from the French Government’s Investissement d’Avenir program, Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases (grant ANR-10-LABX-62-IBEID), the Investissements d’Avenir program (ANR-10-IHUB-0002), ZIKAHOST (ANR-15-CE15-00029), and INSERM. E.S.-L. received funding from the ANR INCEPTION program (Investissements d’Avenir grant ANR-16-CONV-0005). A.L. is supported by a scholarship from the French Ministry of Research.</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-01-20 11:17:14</date>
              <date type="whenModified">2025-08-12 14:56:06</date>
              <date type="whenReleased">2020-01-20 11:17:14</date>
              <date type="whenProduced">2020-03-17</date>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081898"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="640679">
                <persName>
                  <forename>Isabelle</forename>
                  <surname>HUE</surname>
                </persName>
                <email type="md5">e0c7f5a97ee2162a259541b971b2e5f1</email>
                <email type="domain">i2bc.paris-saclay.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02445470</idno>
            <idno type="halUri">https://hal.science/hal-02445470</idno>
            <idno type="halBibtex">labeau:hal-02445470</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Virology&lt;/i&gt;, 2020, 94, pp.e01751-19. &lt;a target="_blank" href="https://dx.doi.org/10.1128/JVI.01751-19"&gt;&amp;#x27E8;10.1128/JVI.01751-19&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Virology, 2020, 94, pp.e01751-19. &amp;#x27E8;10.1128/JVI.01751-19&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="PASTEUR">Institut Pasteur</idno>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="CDF">Collège de France</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="DSV" corresp="CEA">Direction de la recherche fondamentale - sciences du vivant</idno>
            <idno type="stamp" n="CEA-UPSAY" corresp="CEA">CEA - Université Paris-Saclay</idno>
            <idno type="stamp" n="I2BC">I2BC</idno>
            <idno type="stamp" n="PSL">Université Paris sciences et lettres</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="JOLIOT" corresp="CEA">Institut des Sciences du Vivant Frédéric JOLIOT</idno>
            <idno type="stamp" n="CEA-DRF" corresp="CEA">Direction de Recherche Fondamentale</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="CDF-PSL" corresp="PSL">Collège de France - PSL </idno>
            <idno type="stamp" n="UNIVERSITE-PARIS-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="GS-ENGINEERING">Graduate School Sciences de l'Ingénierie et des Systèmes</idno>
            <idno type="stamp" n="GS-BIOSPHERA">Graduate School Biologie, Société, Ecologie &amp; Environnement, Ressources, Agriculture &amp; Alimentation</idno>
            <idno type="stamp" n="GS-LIFE-SCIENCES-HEALTH" corresp="UNIVERSITE-PARIS-SACLAY">Graduate School Life Sciences and Health</idno>
            <idno type="stamp" n="GS-HEALTH-DRUG-SCIENCES">Graduate School Health and Drug Sciences</idno>
            <idno type="stamp" n="INSTITUT-SCIENCES-LUMIERE">Institut des Sciences de la Lumière</idno>
            <idno type="stamp" n="VIR-IMMUN" corresp="PASTEUR">Virus et Immunité - Virus and immunity </idno>
            <idno type="stamp" n="PASTEUR_UMR3569" corresp="PASTEUR">Virologie</idno>
            <idno type="stamp" n="APT_TEST">APT_TEST</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">A genome-wide CRISPR-Cas9 screen identifies the dolichol-phosphate mannose synthase complex as a host dependency factor for dengue virus infection</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Athena</forename>
                    <surname>Labeau</surname>
                  </persName>
                  <idno type="halauthorid">1356610-0</idno>
                  <affiliation ref="#struct-1005063"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Etienne</forename>
                    <surname>Simon-Loriere</surname>
                  </persName>
                  <email type="md5">4de6ffa92427a64feed56970e9781af0</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="string">etiennesimon-loriere</idno>
                  <idno type="idhal" notation="numeric">734968</idno>
                  <idno type="halauthorid" notation="string">19689-734968</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8420-7743</idno>
                  <idno type="IDREF">https://www.idref.fr/136869076</idno>
                  <affiliation ref="#struct-526159"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mohamed-Lamine</forename>
                    <surname>Hafirassou</surname>
                  </persName>
                  <idno type="halauthorid">1682321-0</idno>
                  <affiliation ref="#struct-1005063"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lucie</forename>
                    <surname>Bonnet-Madin</surname>
                  </persName>
                  <idno type="halauthorid">1356611-0</idno>
                  <affiliation ref="#struct-1005063"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sarah</forename>
                    <surname>Tessier</surname>
                  </persName>
                  <idno type="halauthorid">1315721-0</idno>
                  <affiliation ref="#struct-1005063"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alessia</forename>
                    <surname>Zamborlini</surname>
                  </persName>
                  <email type="md5">08d01298eb798a98a490cafc1ab932d4</email>
                  <email type="domain">universite-paris-saclay.fr</email>
                  <idno type="idhal" notation="string">alessia-zamborlini</idno>
                  <idno type="idhal" notation="numeric">1359625</idno>
                  <idno type="halauthorid" notation="string">212254-1359625</idno>
                  <idno type="IDREF">https://www.idref.fr/202911039</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=PPu-d5UAAAAJ</idno>
                  <affiliation ref="#struct-1005063"/>
                  <affiliation ref="#struct-414518"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thierry</forename>
                    <surname>Dupré</surname>
                  </persName>
                  <idno type="halauthorid">375455-0</idno>
                  <affiliation ref="#struct-300156"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nathalie</forename>
                    <surname>Seta</surname>
                  </persName>
                  <idno type="halauthorid">252914-0</idno>
                  <affiliation ref="#struct-300156"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Schwartz</surname>
                  </persName>
                  <email type="md5">fe5083020856ea33a909646be8fe5974</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="numeric">999827</idno>
                  <idno type="halauthorid" notation="string">217629-999827</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0729-1475</idno>
                  <idno type="IDREF">https://www.idref.fr/128673850</idno>
                  <affiliation ref="#struct-410873"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Laure</forename>
                    <surname>Chaix</surname>
                  </persName>
                  <idno type="halauthorid">121406-0</idno>
                  <affiliation ref="#struct-1005063"/>
                  <affiliation ref="#struct-506757"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Constance</forename>
                    <surname>Delaugerre</surname>
                  </persName>
                  <idno type="halauthorid">611839-0</idno>
                  <affiliation ref="#struct-1005063"/>
                  <affiliation ref="#struct-506757"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Ali</forename>
                    <surname>Amara</surname>
                  </persName>
                  <email type="md5">7df1e5129b50bf2523cfd6c374fb4934</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="numeric">864445</idno>
                  <idno type="halauthorid" notation="string">222912-864445</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0283-1815</idno>
                  <affiliation ref="#struct-1005063"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Laurent</forename>
                    <surname>Meertens</surname>
                  </persName>
                  <email type="md5">fa00e8c2777218ef9fa650b845af67bb</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="numeric">1057925</idno>
                  <idno type="halauthorid" notation="string">555111-1057925</idno>
                  <affiliation ref="#struct-1005063"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">6614</idno>
                <idno type="issn">0022-538X</idno>
                <idno type="eissn">1098-5514</idno>
                <title level="j">Journal of Virology</title>
                <imprint>
                  <publisher>American Society for Microbiology</publisher>
                  <biblScope unit="volume">94</biblScope>
                  <biblScope unit="pp">e01751-19</biblScope>
                  <date type="datePub">2020-03-17</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1128/JVI.01751-19</idno>
              <idno type="pubmed">31915280</idno>
              <idno type="pubmedcentral">PMC7081898</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">glycoprotein folding</term>
                <term xml:lang="en">dolichol-phosphate mannose</term>
                <term xml:lang="en">Zika virus</term>
                <term xml:lang="en">N-glycosylation</term>
                <term xml:lang="en">dengue virus</term>
                <term xml:lang="en">dengue fever</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Dengue virus (DENV) is a mosquito-borne flavivirus responsible for dengue disease, a major human health concern for which no specific therapies are available. Like other viruses, DENV relies heavily on the host cellular machinery for productive infection. Here, we performed a genome-wide CRISPR-Cas9 screen using haploid HAP1 cells to identify host genes important for DENV infection. We identified DPM1 and 3, two subunits of the ER resident DPM synthase (DPMS) complex, as host dependency factors for DENV and other related flaviviruses such as Zika virus (ZIKV). DPMS complex catalyzes the synthesis of dolichol-phosphate mannose (DPM) which serves as mannosyl donor in pathways leading to N-glycosylation, GPI anchor biosynthesis and C- or O-mannosylation of proteins in the ER lumen. Mutation in the DXD motif of DPM1, which is essential for its catalytic activity, abolished DPMS-mediated DENV infection. Similarly, genetic ablation of ALG3, a mannosyltransferase that transfers mannose to lipid-linked oligosaccharide (LLO), rendered cells poorly susceptible to DENV. We also established that in cells deficient for DPMS activity, viral RNA amplification is hampered and truncated oligosaccharides are transferred to the viral prM and E glycoproteins, affecting their proper folding. Overall, our study provides new insights into the host dependent mechanisms of DENV infection and supports current therapeutic approaches using glycosylation inhibitors to treat DENV infection.IMPORTANCE Dengue disease, which is caused by dengue virus (DENV), has emerged as the most important mosquito-borne viral disease in humans and is a major global health concern. DENV encodes only few proteins and relies on the host cell machinery to accomplish its life cycle. The identification of the host factors important for DENV infection is needed to propose new targets for antiviral intervention. Using a genome-wide CRISPR-Cas9 screen, we identified DPM1 and 3, two subunits of the DPMS complex, as important host factors for the replication of DENV as well as others related viruses such as Zika virus. We established that DPMS complex plays a dual role during viral infection, both regulating viral RNA replication and promoting viral structural glycoproteins folding/stability. These results provide insights into the host molecules exploited by DENV and other flaviviruses to facilitate their life cycle.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1005063" status="OLD">
          <idno type="RNSR">200918531H</idno>
          <orgName>Génomes, biologie cellulaire et thérapeutiques</orgName>
          <orgName type="acronym">GenCellDis (U944 / UMR7212)</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>Hôpital Saint-Louis - Bâtiment Jean Bernard - 16 rue de la Grange aux Belles, 75010 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://gencelldis.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300026" type="direct"/>
            <relation name="U944" active="#struct-303623" type="direct"/>
            <relation name="UMR7212" active="#struct-441569" type="direct"/>
            <relation name="UMR_S_944/UMR_7212" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-526159" status="OLD">
          <idno type="RNSR">201822712N</idno>
          <orgName>Génomique évolutive des virus à ARN - Evolutionary genomics of RNA viruses</orgName>
          <date type="start">2018-02-01</date>
          <date type="end">2021-07-21</date>
          <desc>
            <address>
              <addrLine>Département de Virologie25-28 rue du Docteur Roux75724 Paris cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://research.pasteur.fr/fr/team/evolutionary-genomics-rna-viruses/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300027" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-414518" status="VALID">
          <idno type="RNSR">201521299R</idno>
          <idno type="ROR">01fftxe08</idno>
          <orgName>Institut de Biologie Intégrative de la Cellule</orgName>
          <orgName type="acronym">I2BC</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Bâtiment 21, 1 avenue de la Terrasse, 91198 Gif/Yvette cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.i2bc.paris-saclay.fr</ref>
          </desc>
          <listRelation>
            <relation name="DRF/I2BC" active="#struct-300016" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
            <relation name="UMR9198" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300156" status="VALID">
          <idno type="ROR">https://ror.org/03fdnmv92</idno>
          <orgName>AP-HP - Hôpital Bichat - Claude Bernard [Paris]</orgName>
          <desc>
            <address>
              <addrLine>46 Rue Henri Huchard, 75018 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://hupnvs.aphp.fr/bichat-claude-bernard/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-410873" status="OLD">
          <idno type="RNSR">200718194A</idno>
          <orgName>Virus et Immunité - Virus and immunity</orgName>
          <orgName type="acronym">CNRS-UMR3569</orgName>
          <date type="end">2021-07-21</date>
          <desc>
            <address>
              <addrLine>Département Virologie, 25-28 rue du Docteur Roux - 75724 Paris CEDEX15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://research.pasteur.fr/fr/team/virus-and-immunity/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300027" type="direct"/>
            <relation name="UMR3569" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-506757" status="VALID">
          <idno type="IdRef">02869614X</idno>
          <idno type="ROR">https://ror.org/049am9t04</idno>
          <orgName>Hopital Saint-Louis [AP-HP]</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <addrLine>1 Avenue Claude Vellefaux, 75010 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://hopital-saintlouis.aphp.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300026" status="VALID">
          <orgName>Collège de France</orgName>
          <orgName type="acronym">CdF (institution)</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300027" status="VALID">
          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <idno type="ROR">https://ror.org/0495fxg12</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <orgName type="acronym">IP</orgName>
          <date type="start">1887-06-04</date>
          <desc>
            <address>
              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300016" status="VALID">
          <idno type="IdRef">026372061</idno>
          <idno type="ISNI">0000000122998025</idno>
          <idno type="ROR">https://ror.org/00jjx8s55</idno>
          <idno type="Wikidata">Q868550</idno>
          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>
            <address>
              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-24021" status="VALID">
          <idno type="anr">ANR-10-LABX-0062</idno>
          <orgName>IBEID</orgName>
          <desc>Integrative Biology of Emerging Infectious Diseases</desc>
          <date type="start">2010</date>
        </org>
        <org type="anrProject" xml:id="projanr-47681" status="VALID">
          <idno type="anr">ANR-16-CONV-0005</idno>
          <orgName>INCEPTION</orgName>
          <desc>Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs</desc>
          <date type="start">2016</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>