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Article Dans Une Revue SN Applied Sciences Année : 2019

2D simulation of a microfluidic biosensor for CRP detection into a rotating micro-channel

Résumé

Previously, pumping systems using centrifugal force has been regarded as an attractive control method for fluid flow interior microchannel. In this work, we propose a novel design of a biosensor for complex reactive protein detection in two-dimensional rotating microchannel using the finite element method. We have first developed the physical mod-eling of the centrifugal force driven, and detailed velocity profile and expended the pressure distribution. Several crucial factors that influence the equilibrium binding time are discussed, including the bulk analyte concentration and the biosensor length. The obtained analytical results reveal that the binding reaction is largely enhanced with the increase of the angular velocity. Hence, an appropriate choice of the angular velocity may enhance the microfluidic biosensor performance and reduce considerably the time response. This work can open new opportunity for further investigation in microflow injection experimental studies.
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Dates et versions

hal-02437021 , version 1 (22-09-2020)

Identifiants

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Mohamed Bahri, Imen Dermoul, Marshet Getaye, Mounir Ben Ali, Abdelhamid Errachid. 2D simulation of a microfluidic biosensor for CRP detection into a rotating micro-channel. SN Applied Sciences, 2019, 1 (10), pp.Article Number: 1199. ⟨10.1007/s42452-019-1231-8⟩. ⟨hal-02437021⟩
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