Classification of biphasic solvent systems according to Abraham descriptors for countercurrent chromatography - Archive ouverte HAL Access content directly
Journal Articles Journal of Chromatography A Year : 2020

Classification of biphasic solvent systems according to Abraham descriptors for countercurrent chromatography

Abstract

8 The method development of liquid-liquid chromatography, either countercurrent 9 chromatography or centrifugal partition chromatography, is slowed down by the selection of 10 the biphasic solvent system that constitutes its column. This paper introduces a classification 11 of 19 solvent systems, including the most popular systems based on heptane/ethyl 12 acetate/methanol/water, some non-aqueous systems and some greener systems. This 13 classification is based on Abraham descriptors determined through the partition coefficients 14 of 43 probes. Among 21 determined models, nine of them allow an accurate prediction of 15 partition coefficients from solute descriptors and another ten provide a description of the 16 chromatographic interactions at the 5% significance level. A graphical tool (spider diagram) is 17 built for the comparison of the chromatographic columns previously characterized with the 18 solvation parameter model. The position of a solvent system in this spider diagram relates to 19 the interactions at stake, thus the selection of columns offering similar or orthogonal 20 interactions is facilitated, with no previous knowledge of the solute required. This semi-21 empirical strategy cannot fully predict the retention behavior but can judiciously orientate the 22 user towards a limited number of solvent systems to be experimentally tested. 23 24
Fichier principal
Vignette du fichier
2020-JCA-Marlot-Batteau-Faure-Classification of biphasic solvent systems according to Abraham descriptors for countercurrent chromatography.pdf (770.93 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-02436965 , version 1 (23-07-2020)

Identifiers

Cite

Léa Marlot, Magali Batteau, Karine Faure. Classification of biphasic solvent systems according to Abraham descriptors for countercurrent chromatography. Journal of Chromatography A, 2020, 1617, pp.460820. ⟨10.1016/j.chroma.2019.460820⟩. ⟨hal-02436965⟩
44 View
73 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More