Bidirectional enantioselective synthesis of bis-benzofuran atropisomeric oligoarenes featuring two distal C-C stereogenic axes
Résumé
We report the bidirectional enantioselective synthesis of bis-benzofuran atropisomeric oligoarenes featuring two distal CC stereogenic axes obtained by a twofold central-to-axial chirality conversion upon oxidative aromatization. The key enantioenriched centrally chiral bis-dihydrobenzofuran precursors were synthesized via a bidirectional diastereo-and enantio-selective organocatalyzed domino reaction between simple achiral and easily accessible dihydroxylated aromatics and chloronitroalkenes. Moreover, the stereodivergent nature of the methodology was established by synthesizing both diastereomers of a non-symmetrically functionalized bis-axially chiral oligoarene.
Domaines
Chimie organiqueOrigine | Fichiers produits par l'(les) auteur(s) |
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