Linking genetic variation with epigenetic profiles in Sjögren's syndrome - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Clinical Immunology Année : 2020

Linking genetic variation with epigenetic profiles in Sjögren's syndrome

Résumé

DNA methylation represents an important regulatory event governing gene expression that is dysregulated in Sjögren's syndrome (SjS) and a number of autoimmune/inflammatory diseases. As disease-associated single-nucleotide polymorphisms (SNPs) have relevance in controlling DNA methylation, 94 non-HLA SjS-SNPs were investigated, among them 57 (60.6%) with widespread effects on 197 individual DNA methylation quantitative trait loci (meQTL) were selected. Typically, these SNPs are intronic, possess an active promoter histone mark, and control cis-meQTLs located around transcription start sites. Interplay is independent of the physical distance between SNPs and meQTLs. Using epigenome-wide association study datasets, SjS-meQTLs were characterized (41 genes and 13 DNA methylation CpG motifs) and for the most part map to a pro-inflammatory cytokine pathway, which is important for the control of DNA methylation in autoimmune diseases. In conclusion, exploring meQTLs represents a valuable tool to predict and investigate downstream effects of genetic factors in complex diseases such as SjS.
Fichier principal
Vignette du fichier
S1521661619305972.pdf (1.36 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-02431049 , version 1 (21-07-2022)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Pinelopi Arvaniti, Christelle Le Dantec, Amandine Charras, Marina Arleevskaya, Christian Hedrich, et al.. Linking genetic variation with epigenetic profiles in Sjögren's syndrome. Clinical Immunology, 2020, 210, pp.108314. ⟨10.1016/j.clim.2019.108314⟩. ⟨hal-02431049⟩
187 Consultations
73 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More