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Article Dans Une Revue Nutrients Année : 2018

Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants

El Mostafa Qannari
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Mikael Croyal
Mohamed Soumah
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Agnès David-Sochard

Résumé

Human milk is recommended for feeding preterm infants. The current pilot study aims to determine whether breast-milk lipidome had any impact on the early growth-pattern of preterm infants fed their own mother's milk. A prospective-monocentric-observational birth-cohort was established, enrolling 138 preterm infants, who received their own mother's breast-milk throughout hospital stay. All infants were ranked according to the change in weight Z-score between birth and hospital discharge. Then, we selected infants who experienced "slower" (n = 15, −1.54 ± 0.42 Z-score) or "faster" (n = 11, −0.48 ± 0.19 Z-score) growth; as expected, although groups did not differ regarding gestational age, birth weight Z-score was lower in the "faster-growth" group (0.56 ± 0.72 vs. −1.59 ± 0.96). Liquid chromatography-mass spectrometry lipidomic signatures combined with multivariate analyses made it possible to identify breast-milk lipid species that allowed clear-cut discrimination between groups. Validation of the selected biomarkers was performed using multidimensional statistical, false-discovery-rate and ROC (Receiver Operating Characteristic) tools. Breast-milk associated with faster growth contained more medium-chain saturated fatty acid and sphingomyelin, dihomo-γ-linolenic acid (DGLA)-containing phosphethanolamine, and less oleic acid-containing triglyceride and DGLA-oxylipin. The ability of such biomarkers to predict early-growth was validated in presence of confounding clinical factors but remains to be ascertained in larger cohort studies.
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hal-02429557 , version 1 (06-01-2020)

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Marie Cécile Alexandre-Gouabau, Thomas Moyon, Véronique Cariou, Jean-Philippe Antignac, El Mostafa Qannari, et al.. Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants. Nutrients, 2018, 10 (2), pp.164. ⟨10.3390/nu10020164⟩. ⟨hal-02429557⟩
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