Inhibition of β -carbonic anhydrases from Brucella suis with C -cinnamoyl glycosides incorporating the phenol moiety - Archive ouverte HAL Access content directly
Journal Articles Journal of Enzyme Inhibition and Medicinal Chemistry Year : 2014

Inhibition of β -carbonic anhydrases from Brucella suis with C -cinnamoyl glycosides incorporating the phenol moiety

Abstract

A small series of C-glycosides containing the phenol moiety was tested for the inhibition of the β-class carbonic anhydrases (βCAs, EC 4.2.1.1) from Brucella suis. Many compounds showed activities in the micromolar or submicromolar range and excellent selectivity for pathogen CAs over human isozymes. Glycosides incorporating the 3-hydroxyphenyl moiety showed the best inhibition profile, and therefore this functionality represents lead for the development of novel anti-infectives with a new mechanism of action.
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Dates and versions

hal-02425101 , version 1 (08-01-2020)

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Leonardo Riafrecha, Daniela Vullo, Safia Ouahrani-Bettache, Stephan Köhler, Pascal Dumy, et al.. Inhibition of β -carbonic anhydrases from Brucella suis with C -cinnamoyl glycosides incorporating the phenol moiety. Journal of Enzyme Inhibition and Medicinal Chemistry, 2014, 30 (6), pp.1017-1020. ⟨10.3109/14756366.2014.986120⟩. ⟨hal-02425101⟩
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