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Journal Articles Clinical Infectious Diseases Year : 2018

Prosthetic Valve Candida spp. Endocarditis: New Insights Into Long-term Prognosis—The ESCAPE Study

Claire Rivoisy (1) , Antonio Vena (2, 3, 4) , Laura Schaeffer (5) , Caroline Charlier (1) , Arnaud Fontanet (5, 6) , François Delahaye (7, 8) , Emilio Bouza (2, 4, 3) , Olivier Lortholary (1, 9) , Patricia Muñoz (2, 4, 3) , Agnès Lefort (10, 11) , Yazdan Yazdanpanah (11) , Michel Wolff , Sandrine Houze (12) , Tristan Ferry , Martine Wallon (13) , Christophe Strady , Dominique Toubas (14) , Nicolas Bréchot (15) , Benoît Henry (16) , Arnaud Fekkar (16) , Thierry Fourme , Isabelle Amouroux , Jean-Luc Mainardi (17) , Eric Dannaoui (9) , Olivier Rogeaux (18) , Marion Levast (19) , Catherine Chirouze (20) , Laurence Million (20) , Frédéric Bastides (21) , Jacques Chandenier (22) , Jean-Pierre Lançon , Anne Ovize (23) , Pierre Abgueguen (24) , Jean-Philippe Bouchara (25) , Laurent Tric , Gilbert Habib (26) , Frederic Gourriet , Laurent Aaron , Marie Elisabeth Bougnoux (27) , Fabrice Camou (28) , Isabelle Accoceberry (29) , Fernando Fernández Sánchez , Mariam Noureddine , Gabriel Rosas , Javier de La Torre Lima , José Aramendi , Elena Bereciartua , María Victoria Boado , Marta Campaña Lázaro , Josune Goikoetxea , Juan José Goiti , José Luis Hernández , José Ramón Iruretagoyena , Josu Irurzun Zuazabal , Leire López-Soria , Miguel Montejo , Pedro María Pérez , Regino Rodríguez , Roberto Voces , Mª Victoria García López , Radka Ivanova Georgieva , Manuel Márquez Solero , Isabel Rodríguez Bailón , Josefa Ruiz Morales , Ana María Cuende , Tomás Echeverría , Ana Fuerte , Eduardo Gaminde , Miguel Ángel Goenaga , Pedro Idígoras , José Antonio Iribarren , Alberto Izaguirre Yarza , Xabier Kortajarena Urkola , Carlos Reviejo , Rafael C. Carrasco (30) , Vicente Climent , Patricio Llamas , Esperanza Merino , Joaquín Plazas , Sergio Reus , Nemesio Álvarez , Jose María Bravo-Ferrer , Laura Castelo , José Cuenca , Pedro Llinares , Enrique Miguez Rey , María Rodríguez Mayo , Efrén Sánchez , Dolores Sousa Regueiro , Francisco Javier Martinez (31) , Mª del Mar Alonso , Beatriz Castro , Dácil García Marrero , Mª del Carmen Durán , Mª Antonia Miguel Gómez , Juan La Calzada , Ibrahim Nassar , Antonio Plata Ciezar , José Mª Reguera Iglesias , Víctor Asensio , Carlos Costas , Jesús de La Hera , Jonnathan Fernández Suárez , Lisardo Iglesias Fraile , Víctor León Arguero , José López Menéndez , Pilar Menciabajo , Carlos R. Morales (32) , Alfonso Moreno Torrico , Carmen Palomo , Begoña Paya Martínez , Ángeles Rodríguez Esteban , Raquel Rodríguez García , Mauricio Telenti Asensio , Manuel Almela , Yolanda Armero , Manuel Azqueta , Merce Brunet (33) , Ramón Cartañá , Carlos Cervera , Carlos Falces , Guillermina Fita , David Fuster , Cristina García de La Maria , José Gatell (34) , Jaume Llopis Pérez , Francesc Marco , Carlos Mestres , José Mª Miró , Asunción Moreno , Salvador Ninot , Eduardo Quintana , Carlos Paré , Juan Manuel Pericás , José Pomar , José Ramírez (35) , Irene Rovira , Marta Sitges (36) , Dolors Soy , Adrián Téllez , Jordi Vila , Javier Bermejo , Gregorio Cuerpo , Viviana de Egea , Alia Eworo , Ana Fernández Cruz , Mª Eugenia García Leoni , Marcela González del Vecchio , Víctor González Ramallo , Martha Kestler Hernández , Mercedes Marín , Manuel Martínez-Sellés , Mª Cruz Menárguez , Cristina Rincón , Hugo Rodríguez-Abella , Marta Rodríguez-Créixems , Blanca Pinilla , Ángel Pinto , Maricela Valerio , Eduardo Verde Moreno , Isabel Antorrena , Belén Loeches , Mar Moreno , Ulises Ramírez , Verónica Rial Bastón , María Romero , Araceli Saldaña , Carlos Armiñanzas Castillo , Ana Arnaiz , José Berrazueta , Sara Bellisco , Manuel Cobo Belaustegui , Raquel Durán , Mªcarmen Fariñas , Concepción Fariñas-Álvarez , Carlos Fernández Mazarrasa , Rubén Gómez Izquierdo , Claudia González Rico , José Gutiérrez Díez , Rafael Martín Durán , Marcos Pajarón , José Antonio Parra , Ramón Teira , Jesús Zarauza , Pablo García Pavía , Jesús González , Beatriz Orden , Antonio Ramos (37) , Elena Rodríguez González , Tomasa Centella , José Manuel Hermida , José Luis Moya , Pilar Martín-Dávila , Enrique Navas , Enrique Oliva , Alejandro del Río , Soledad Ruiz , Carmen Hidalgo Tenorio , Antonio de Castro , Marina de Cueto , Pastora Gallego , Juan Gálvez Acebal , Jesús Rodríguez Baño , Arístides de Alarcón , Emilio García , Juan Luis Haro , José Antonio Lepe , Francisco López , Rafael Luque (38) , Luis Javier Alonso , José Manuel Azcona Gutiérrez , José Ramón Blanco , Lara García , José Antonio Oteo , Natividad de Benito , Mercé Gurguí , Cristina Pacho , Roser Pericas (39) , Guillem Pons , M. Alvarez (40) , A Fernández , A. Prieto (41) , Benito Regueiro , E Tijeira , Marino Vega , Andrés Canut Blasco , José Cordo Mollar , Juan Carlos Gainzarain Arana , Oscar García Uriarte , Alejandro Martín López , Zuriñe Ortiz de Zárate , José Antonio Urturi Matos , Mª Belén Nacle , Antonio Sánchez-Porto , Luis Vallejo , José Mª Arribasleal , Elisa García Vázquez , Alicia Hernández Torres , Ana Blázquez , Gonzalo de La Morena Valenzuela , Ángel Alonso , Javier Aramburu , Felicitas Elena Calvo , Anai Moreno Rodríguez , Paola Tarabini-Castellani , Eva Heredero Gálvez , Carolina Maicas Bellido , José Largo Pau , Mª Antonia Sepúlveda , Pilar Toledano Sierra , Sadaf Zafar Iqbal-Mirza , Eva Cascales Alcolea , Pilar Egea Serrano , José Joaquín Hernández Roca
1 Service des Maladies infectieuses et tropicales [CHU Necker]
2 Hospital General Universitario "Gregorio Marañón" [Madrid]
3 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
4 CIBERES - Centro de Investigación Biomédica en Red Enfermedades Respiratorias
5 Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology
6 PACRI - Pasteur-Cnam Risques infectieux et émergents
7 UCBL - Université Claude Bernard Lyon 1
8 HCL - Hospices Civils de Lyon
9 Mycologie moléculaire
10 Hôpital Beaujon
11 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
12 MERIT - UMR_D 216 - Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique
13 Service de Parasitologie
14 MEDyC - Matrice extracellulaire et dynamique cellulaire - UMR 7369
15 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
16 CHU Pitié-Salpêtrière [AP-HP]
17 HEGP - Hôpital Européen Georges Pompidou [APHP]
18 Service des Maladies Infectieuses
19 Laboratoire de Bactériologie
20 LCE - Laboratoire Chrono-environnement (UMR 6249)
21 Service de Médecine Interne et Maladies Infectieuses [Tours]
22 CHU Tours, Service de Parasitologie - Mycologie - Médecine Tropicale
23 Eurofins Biomnis
24 Service des maladies infectieuses et tropicales [CHU Angers]
25 GEIHP - Groupe d'Étude des Interactions Hôte-Pathogène
26 Service de cardiologie
27 BPF - Biologie et Pathogénicité fongiques
28 Hôpital St-André, Réanimation
29 MFP - Microbiologie Fondamentale et Pathogénicité
30 UPA - Universitad Politecnica de Alicante
31 ITA - Instituto Tecnologico de Aragon
32 Department of Anatomy and Cell Biology [Montréal]
33 UB - Universitat de Barcelona
34 AIDS Research Group [Barcelona, Spain]
35 Instituto Tecnológico de Tláhuac
36 Cardiology Department, Thorax Clinic Institute, Hospital Cliınic, Institut d'Investigacions Biomèdiques [Barcelona]
37 Universidade de Aveiro
38 Universidad de Córdoba = University of Córdoba [Córdoba]
39 Department of Microbiology
40 URV - University Rovirai Virgili de Tarragona
41 Chercheur indépendant
Michel Wolff
  • Function : Author
Tristan Ferry
  • Function : Author
Christophe Strady
  • Function : Author
Benoît Henry
Arnaud Fekkar
  • Function : Author
  • PersonId : 921964
Thierry Fourme
  • Function : Author
Isabelle Amouroux
  • Function : Author
Eric Dannaoui
Laurence Million
  • Function : Author
  • PersonId : 781458
  • IdRef : 160473640
Jean-Pierre Lançon
  • Function : Author
Anne Ovize
  • Function : Author
Laurent Tric
  • Function : Author
Gilbert Habib
Frederic Gourriet
  • Function : Author
Laurent Aaron
  • Function : Author
Fernando Fernández Sánchez
  • Function : Author
Mariam Noureddine
  • Function : Author
Gabriel Rosas
  • Function : Author
Javier de La Torre Lima
  • Function : Author
José Aramendi
  • Function : Author
Elena Bereciartua
  • Function : Author
María Victoria Boado
  • Function : Author
Marta Campaña Lázaro
  • Function : Author
Josune Goikoetxea
  • Function : Author
Juan José Goiti
  • Function : Author
José Luis Hernández
  • Function : Author
José Ramón Iruretagoyena
  • Function : Author
Josu Irurzun Zuazabal
  • Function : Author
Leire López-Soria
  • Function : Author
Miguel Montejo
  • Function : Author
Pedro María Pérez
  • Function : Author
Regino Rodríguez
  • Function : Author
Roberto Voces
  • Function : Author
Mª Victoria García López
  • Function : Author
Radka Ivanova Georgieva
  • Function : Author
Manuel Márquez Solero
  • Function : Author
Isabel Rodríguez Bailón
  • Function : Author
Josefa Ruiz Morales
  • Function : Author
Ana María Cuende
  • Function : Author
Tomás Echeverría
  • Function : Author
Ana Fuerte
  • Function : Author
Eduardo Gaminde
  • Function : Author
Miguel Ángel Goenaga
  • Function : Author
Pedro Idígoras
  • Function : Author
José Antonio Iribarren
  • Function : Author
Alberto Izaguirre Yarza
  • Function : Author
Xabier Kortajarena Urkola
  • Function : Author
Carlos Reviejo
  • Function : Author
Vicente Climent
  • Function : Author
Patricio Llamas
  • Function : Author
Esperanza Merino
  • Function : Author
Joaquín Plazas
  • Function : Author
Sergio Reus
  • Function : Author
Nemesio Álvarez
  • Function : Author
Jose María Bravo-Ferrer
  • Function : Author
Laura Castelo
  • Function : Author
José Cuenca
  • Function : Author
Pedro Llinares
  • Function : Author
Enrique Miguez Rey
  • Function : Author
María Rodríguez Mayo
  • Function : Author
Efrén Sánchez
  • Function : Author
Dolores Sousa Regueiro
  • Function : Author
Mª del Mar Alonso
  • Function : Author
Beatriz Castro
  • Function : Author
Dácil García Marrero
  • Function : Author
Mª del Carmen Durán
  • Function : Author
Mª Antonia Miguel Gómez
  • Function : Author
Juan La Calzada
  • Function : Author
Ibrahim Nassar
  • Function : Author
Antonio Plata Ciezar
  • Function : Author
José Mª Reguera Iglesias
  • Function : Author
Víctor Asensio
  • Function : Author
Carlos Costas
  • Function : Author
Jesús de La Hera
  • Function : Author
Jonnathan Fernández Suárez
  • Function : Author
Lisardo Iglesias Fraile
  • Function : Author
Víctor León Arguero
  • Function : Author
José López Menéndez
  • Function : Author
Pilar Menciabajo
  • Function : Author
Alfonso Moreno Torrico
  • Function : Author
Carmen Palomo
  • Function : Author
Begoña Paya Martínez
  • Function : Author
Ángeles Rodríguez Esteban
  • Function : Author
Raquel Rodríguez García
  • Function : Author
Mauricio Telenti Asensio
  • Function : Author
Manuel Almela
  • Function : Author
Yolanda Armero
  • Function : Author
Manuel Azqueta
  • Function : Author
Ramón Cartañá
  • Function : Author
Carlos Cervera
  • Function : Author
Carlos Falces
  • Function : Author
Guillermina Fita
  • Function : Author
David Fuster
  • Function : Author
Cristina García de La Maria
  • Function : Author
José Gatell
  • Function : Author
  • PersonId : 1022623
Jaume Llopis Pérez
  • Function : Author
Francesc Marco
  • Function : Author
Carlos Mestres
  • Function : Author
José Mª Miró
  • Function : Author
Asunción Moreno
  • Function : Author
Salvador Ninot
  • Function : Author
Eduardo Quintana
  • Function : Author
Carlos Paré
  • Function : Author
Juan Manuel Pericás
  • Function : Author
José Pomar
  • Function : Author
José Ramírez
  • Function : Author
  • PersonId : 1051222
Irene Rovira
  • Function : Author
Dolors Soy
  • Function : Author
Adrián Téllez
  • Function : Author
Jordi Vila
  • Function : Author
Javier Bermejo
  • Function : Author
Gregorio Cuerpo
  • Function : Author
Viviana de Egea
  • Function : Author
Alia Eworo
  • Function : Author
Ana Fernández Cruz
  • Function : Author
Mª Eugenia García Leoni
  • Function : Author
Marcela González del Vecchio
  • Function : Author
Víctor González Ramallo
  • Function : Author
Martha Kestler Hernández
  • Function : Author
Mercedes Marín
  • Function : Author
Manuel Martínez-Sellés
Mª Cruz Menárguez
  • Function : Author
Cristina Rincón
  • Function : Author
Hugo Rodríguez-Abella
  • Function : Author
Marta Rodríguez-Créixems
  • Function : Author
Blanca Pinilla
  • Function : Author
Ángel Pinto
  • Function : Author
Maricela Valerio
  • Function : Author
Eduardo Verde Moreno
  • Function : Author
Isabel Antorrena
  • Function : Author
Belén Loeches
  • Function : Author
Mar Moreno
  • Function : Author
Ulises Ramírez
  • Function : Author
Verónica Rial Bastón
  • Function : Author
María Romero
  • Function : Author
Araceli Saldaña
  • Function : Author
Carlos Armiñanzas Castillo
  • Function : Author
Ana Arnaiz
  • Function : Author
José Berrazueta
  • Function : Author
Sara Bellisco
  • Function : Author
Manuel Cobo Belaustegui
  • Function : Author
Raquel Durán
  • Function : Author
Mªcarmen Fariñas
  • Function : Author
Concepción Fariñas-Álvarez
  • Function : Author
Carlos Fernández Mazarrasa
  • Function : Author
Rubén Gómez Izquierdo
  • Function : Author
Claudia González Rico
  • Function : Author
José Gutiérrez Díez
  • Function : Author
Rafael Martín Durán
  • Function : Author
Marcos Pajarón
  • Function : Author
José Antonio Parra
  • Function : Author
Ramón Teira
  • Function : Author
Jesús Zarauza
  • Function : Author
Pablo García Pavía
  • Function : Author
Jesús González
  • Function : Author
Beatriz Orden
  • Function : Author
Antonio Ramos
  • Function : Author
  • PersonId : 1043579
Elena Rodríguez González
  • Function : Author
Tomasa Centella
  • Function : Author
José Manuel Hermida
  • Function : Author
José Luis Moya
  • Function : Author
Pilar Martín-Dávila
  • Function : Author
Enrique Navas
  • Function : Author
Enrique Oliva
  • Function : Author
Alejandro del Río
  • Function : Author
Soledad Ruiz
  • Function : Author
Carmen Hidalgo Tenorio
  • Function : Author
Antonio de Castro
  • Function : Author
Marina de Cueto
  • Function : Author
Pastora Gallego
  • Function : Author
Juan Gálvez Acebal
  • Function : Author
Jesús Rodríguez Baño
  • Function : Author
Arístides de Alarcón
  • Function : Author
Emilio García
  • Function : Author
Juan Luis Haro
  • Function : Author
José Antonio Lepe
  • Function : Author
Francisco López
  • Function : Author
Luis Javier Alonso
  • Function : Author
José Manuel Azcona Gutiérrez
  • Function : Author
José Ramón Blanco
  • Function : Author
Lara García
  • Function : Author
José Antonio Oteo
  • Function : Author
Natividad de Benito
  • Function : Author
Mercé Gurguí
  • Function : Author
Cristina Pacho
  • Function : Author
Roser Pericas
  • Function : Author
  • PersonId : 907168
Guillem Pons
  • Function : Author
A Fernández
  • Function : Author
A. Prieto
  • Function : Author
Benito Regueiro
  • Function : Author
E Tijeira
  • Function : Author
Marino Vega
  • Function : Author
Andrés Canut Blasco
  • Function : Author
José Cordo Mollar
  • Function : Author
Juan Carlos Gainzarain Arana
  • Function : Author
Oscar García Uriarte
  • Function : Author
Alejandro Martín López
  • Function : Author
Zuriñe Ortiz de Zárate
  • Function : Author
José Antonio Urturi Matos
  • Function : Author
Mª Belén Nacle
  • Function : Author
Antonio Sánchez-Porto
  • Function : Author
Luis Vallejo
  • Function : Author
José Mª Arribasleal
  • Function : Author
Elisa García Vázquez
  • Function : Author
Alicia Hernández Torres
  • Function : Author
Ana Blázquez
  • Function : Author
Ángel Alonso
  • Function : Author
Javier Aramburu
  • Function : Author
Felicitas Elena Calvo
  • Function : Author
Anai Moreno Rodríguez
  • Function : Author
Paola Tarabini-Castellani
  • Function : Author
Eva Heredero Gálvez
  • Function : Author
Carolina Maicas Bellido
  • Function : Author
José Largo Pau
  • Function : Author
Mª Antonia Sepúlveda
  • Function : Author
Pilar Toledano Sierra
  • Function : Author
Sadaf Zafar Iqbal-Mirza
  • Function : Author
Eva Cascales Alcolea
  • Function : Author
Pilar Egea Serrano
  • Function : Author
José Joaquín Hernández Roca
  • Function : Author

Abstract

Background: Prosthetic valve endocarditis caused by Candida spp. (PVE-C) is rare and devastating, with international guidelines based on expert recommendations supporting the combination of surgery and subsequent azole treatment. Methods: We retrospectively analyzed PVE-C cases collected in Spain and France between 2001 and 2015, with a focus on management and outcome. Results: Forty-six cases were followed up for a median of 9 months. Twenty-two patients (48%) had a history of endocarditis, 30 cases (65%) were nosocomial or healthcare related, and 9 (20%) patients were intravenous drug users. "Induction" therapy consisted mainly of liposomal amphotericin B (L-amB)-based (n = 21) or echinocandin-based therapy (n = 13). Overall, 19 patients (41%) were operated on. Patients <66 years old and without cardiac failure were more likely to undergo cardiac surgery (adjusted odds ratios [aORs], 6.80 [95% confidence interval [CI], 1.59-29.13] and 10.92 [1.15-104.06], respectively). Surgery was not associated with better survival rates at 6 months. Patients who received L-amB alone had a better 6-month survival rate than those who received an echinocandin alone (aOR, 13.52; 95% CI, 1.03-838.10). "Maintenance" fluconazole therapy, prescribed in 21 patients for a median duration of 13 months (range, 2-84 months), led to minor adverse effects. Conclusion: L-amB induction treatment improves survival in patients with PVE-C. Medical treatment followed by long-term maintenance fluconazole may be the best treatment option for frail patients.

Dates and versions

hal-02407034 , version 1 (12-12-2019)

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Claire Rivoisy, Antonio Vena, Laura Schaeffer, Caroline Charlier, Arnaud Fontanet, et al.. Prosthetic Valve Candida spp. Endocarditis: New Insights Into Long-term Prognosis—The ESCAPE Study. Clinical Infectious Diseases, 2018, 66 (6), pp.825-832. ⟨10.1093/cid/cix913⟩. ⟨hal-02407034⟩
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