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Communication Dans Un Congrès Année : 2019

Research and development of effective optical technologies for diagnostics in dermatology

Sergey Zaytsev
Marine Amouroux

Résumé

Optical clearing of the human skin under the action of hyaluronic acid (HA) as an enhancer for optical clearing by polyethylene glycol (PEG-300) was studied in vivo by optical coherent tomography (OCT) method on the wavelength 930±5 nm. The results have showed an increase in the transparency of the epidermis at the optical depth of 50±5 μm by 44±9% within 15 min with the use of a solution of HA in combination with sonophoresis before application of PEG-300 to the skin surface. At the same time, when using PEG-300 without preliminary treatment of the skin with the HA, an increase in the transparency of the epidermis at the same depth was 21±8% within 25 min. In dermis at the depth of 500 μm the OCT signal in the experimental group increased more than 1.6 fold what indicates an increasing of optical probing depth.
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Dates et versions

hal-02403635 , version 1 (10-12-2019)

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Vadim D. Genin, Prisca Rakotomanga, Sergey Zaytsev, Elina A. Genina, Ekaterina N. Lazareva, et al.. Research and development of effective optical technologies for diagnostics in dermatology. Saratov Fall Meeting, SFM'18 - Optical and Nano-Technologies for Biology and Medicine, Sep 2018, Saratov, Russia. ⟨10.1117/12.2528700⟩. ⟨hal-02403635⟩
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