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Article Dans Une Revue Trends in Neurosciences Année : 2013

Neurons as targets for T cells in the nervous system

Résumé

Accumulating evidence shows that T cells penetrate the central nervous system (CNS) parenchyma in several autoimmune, infectious, and degenerative neurological diseases. The structural and functional consequences for CNS neurons of their encounter with activated T cells have been investigated in several experimental systems, including ex vivo co-cultures, electrophysiology, and in vivo imaging. Here, we review the modalities of neuron/T cell interactions. We substantiate the contention that T cells are directly responsible for neuronal damage in a large number of neurological diseases and discuss mechanisms of neuronal damage mediated by distinct T cell subsets, the impact of which differs depending on the disease. Finally, we describe how a better understanding of the mechanisms at play offers new possibilities for therapeutic intervention.
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Dates et versions

hal-02402675 , version 1 (08-10-2021)

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Roland Liblau, Daniel Gonzalez-Dunia, Heinz Wiendl, Frauke Zipp. Neurons as targets for T cells in the nervous system. Trends in Neurosciences, 2013, 36 (6), pp.315-324. ⟨10.1016/j.tins.2013.01.008⟩. ⟨hal-02402675⟩
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